Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation.
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. / Petrone, Angiola; Battaglia, Fortunato; Wang, Cheng; Dusa, Adina; Su, Jing; Zagzag, David; Bianchi, Riccardo; Casaccia-Bonnefil, Patrizia; Arancio, Ottavio; Sap, Jan.
In: EMBO Journal, Vol. 22, No. 16, 2003, p. 4121-31.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation.
AU - Petrone, Angiola
AU - Battaglia, Fortunato
AU - Wang, Cheng
AU - Dusa, Adina
AU - Su, Jing
AU - Zagzag, David
AU - Bianchi, Riccardo
AU - Casaccia-Bonnefil, Patrizia
AU - Arancio, Ottavio
AU - Sap, Jan
N1 - Keywords: Animals; Behavior, Animal; Cell Movement; Gene Expression Regulation, Developmental; Hippocampus; Long-Term Potentiation; Maze Learning; Mice; Mice, Knockout; Mutation; Neuronal Plasticity; Neurons; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptors, Cell Surface
PY - 2003
Y1 - 2003
N2 - Despite clear indications of their importance in lower organisms, the contributions of protein tyrosine phosphatases (PTPs) to development or function of the mammalian nervous system have been poorly explored. In vitro studies have indicated that receptor protein tyrosine phosphatase alpha (RPTPalpha) regulates SRC family kinases, potassium channels and NMDA receptors. Here, we report that absence of RPTPalpha compromises correct positioning of pyramidal neurons during development of mouse hippocampus. Thus, RPTPalpha is a novel member of the functional class of genes that control radial neuronal migration. The migratory abnormality likely results from a radial glial dysfunction rather than from a neuron-autonomous defect. In spite of this aberrant development, basic synaptic transmission from the Schaffer collateral pathway to CA1 pyramidal neurons remains intact in Ptpra(-/-) mice. However, these synapses are unable to undergo long-term potentiation. Mice lacking RPTPalpha also underperform in the radial-arm water-maze test. These studies identify RPTPalpha as a key mediator of neuronal migration and synaptic plasticity.
AB - Despite clear indications of their importance in lower organisms, the contributions of protein tyrosine phosphatases (PTPs) to development or function of the mammalian nervous system have been poorly explored. In vitro studies have indicated that receptor protein tyrosine phosphatase alpha (RPTPalpha) regulates SRC family kinases, potassium channels and NMDA receptors. Here, we report that absence of RPTPalpha compromises correct positioning of pyramidal neurons during development of mouse hippocampus. Thus, RPTPalpha is a novel member of the functional class of genes that control radial neuronal migration. The migratory abnormality likely results from a radial glial dysfunction rather than from a neuron-autonomous defect. In spite of this aberrant development, basic synaptic transmission from the Schaffer collateral pathway to CA1 pyramidal neurons remains intact in Ptpra(-/-) mice. However, these synapses are unable to undergo long-term potentiation. Mice lacking RPTPalpha also underperform in the radial-arm water-maze test. These studies identify RPTPalpha as a key mediator of neuronal migration and synaptic plasticity.
U2 - 10.1093/emboj/cdg399
DO - 10.1093/emboj/cdg399
M3 - Journal article
C2 - 12912911
VL - 22
SP - 4121
EP - 4131
JO - E M B O Journal
JF - E M B O Journal
SN - 0261-4189
IS - 16
ER -
ID: 5069551