Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction. / Lassen, Mats Christian Hojbjerg; Sengelov, Morten; Qasim, Atif; Jørgensen, Peter Godsk; Bruun, Niels Eske; Olsen, Flemming Javier; Fritz-Hansen, Thomas; Gislason, Gunnar; Biering-Sorensen, Tor.

In: Journal of Cardiac Failure, Vol. 25, No. 11, 2019, p. 877-885.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lassen, MCH, Sengelov, M, Qasim, A, Jørgensen, PG, Bruun, NE, Olsen, FJ, Fritz-Hansen, T, Gislason, G & Biering-Sorensen, T 2019, 'Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction', Journal of Cardiac Failure, vol. 25, no. 11, pp. 877-885. https://doi.org/10.1016/j.cardfail.2019.07.007

APA

Lassen, M. C. H., Sengelov, M., Qasim, A., Jørgensen, P. G., Bruun, N. E., Olsen, F. J., Fritz-Hansen, T., Gislason, G., & Biering-Sorensen, T. (2019). Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction. Journal of Cardiac Failure, 25(11), 877-885. https://doi.org/10.1016/j.cardfail.2019.07.007

Vancouver

Lassen MCH, Sengelov M, Qasim A, Jørgensen PG, Bruun NE, Olsen FJ et al. Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction. Journal of Cardiac Failure. 2019;25(11):877-885. https://doi.org/10.1016/j.cardfail.2019.07.007

Author

Lassen, Mats Christian Hojbjerg ; Sengelov, Morten ; Qasim, Atif ; Jørgensen, Peter Godsk ; Bruun, Niels Eske ; Olsen, Flemming Javier ; Fritz-Hansen, Thomas ; Gislason, Gunnar ; Biering-Sorensen, Tor. / Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction. In: Journal of Cardiac Failure. 2019 ; Vol. 25, No. 11. pp. 877-885.

Bibtex

@article{8f0f0be8e22a4d6eb5144407dfdca4fc,
title = "Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction",
abstract = "Aims: The ratio of early mitral inflow velocity to global diastolic strain rate (E/e' sr) has recently emerged as a novel measure of left ventricular (LV) filling pressure. This new measure has demonstrated to have prognostic value superior to E/e'. This study aimed to investigate the prognostic value of E/e' sr in a large cohort of patients with heart failure with reduced ejection fraction (HFrEF) in relation to all-cause mortality. Methods: We retrospectively studied 897 HFrEF (mean age 66 +/- 12 years, 73% male, 59% ischemic cardiomyopathy) patients who underwent speckle tracking echocardiography where E/e' sr along with novel and conventional echocardiographic parameters were obtained. The primary endpoint was defined as all-cause mortality. Results: During follow-up (median: 40 months IQR: 22-57), 137 (15.3%) patients died. Both E/e'sr and E/e' were significantly associated with mortality (E/e' sr: HR 1.03 95%CI [1.02-1.04], p<0.001, per 0.10m increase) and (E/e': HR 1.04 95%CI [1.02-1.06], p = 0.001, per 1 unit increase). E/e' sr remained an independent predictor in a multivariable model after adjusting for age, gender, mean arterial pressure, heart rate, BMI, total cholesterol, diabetes mellitus, ischemic cardiomyopathy, LVEF, LVIDd, LVMI, LAVI, TAPSE and LV-GLS (HR 1.02 95%CI [1.01-1.03], p = 0.007) whereas E/e' did not (HR 1.01 95%CI [0.98-1.04], p = 0.57). Furthermore, E/e'sr provided incremental prognostic information beyond a model including known risk factors: age, gender, total cholesterol, mean arterial pressure, heart rate, BMI, smoking status and E/e' (Harrell's C-statistics: 0.72 (0.68-0.77) vs 0.70 (0.66-0.75), p = 0.047). Conclusions: In HFrEF patients, E/e'sr provides independent and incremental prognostic information regarding all-cause mortality superior to E/e'",
keywords = "Two-dimensional speckle tracking echocardiographic, early diastolic strain rate, global longitudinal strain, systolic heart failure, HFrEF, long-term outcome, filling pressures",
author = "Lassen, {Mats Christian Hojbjerg} and Morten Sengelov and Atif Qasim and J{\o}rgensen, {Peter Godsk} and Bruun, {Niels Eske} and Olsen, {Flemming Javier} and Thomas Fritz-Hansen and Gunnar Gislason and Tor Biering-Sorensen",
year = "2019",
doi = "10.1016/j.cardfail.2019.07.007",
language = "English",
volume = "25",
pages = "877--885",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "11",

}

RIS

TY - JOUR

T1 - Ratio of Transmitral Early Filling Velocity to Early Diastolic Strain Rate Predicts All-Cause Mortality in Heart Failure with Reduced Ejection Fraction

AU - Lassen, Mats Christian Hojbjerg

AU - Sengelov, Morten

AU - Qasim, Atif

AU - Jørgensen, Peter Godsk

AU - Bruun, Niels Eske

AU - Olsen, Flemming Javier

AU - Fritz-Hansen, Thomas

AU - Gislason, Gunnar

AU - Biering-Sorensen, Tor

PY - 2019

Y1 - 2019

N2 - Aims: The ratio of early mitral inflow velocity to global diastolic strain rate (E/e' sr) has recently emerged as a novel measure of left ventricular (LV) filling pressure. This new measure has demonstrated to have prognostic value superior to E/e'. This study aimed to investigate the prognostic value of E/e' sr in a large cohort of patients with heart failure with reduced ejection fraction (HFrEF) in relation to all-cause mortality. Methods: We retrospectively studied 897 HFrEF (mean age 66 +/- 12 years, 73% male, 59% ischemic cardiomyopathy) patients who underwent speckle tracking echocardiography where E/e' sr along with novel and conventional echocardiographic parameters were obtained. The primary endpoint was defined as all-cause mortality. Results: During follow-up (median: 40 months IQR: 22-57), 137 (15.3%) patients died. Both E/e'sr and E/e' were significantly associated with mortality (E/e' sr: HR 1.03 95%CI [1.02-1.04], p<0.001, per 0.10m increase) and (E/e': HR 1.04 95%CI [1.02-1.06], p = 0.001, per 1 unit increase). E/e' sr remained an independent predictor in a multivariable model after adjusting for age, gender, mean arterial pressure, heart rate, BMI, total cholesterol, diabetes mellitus, ischemic cardiomyopathy, LVEF, LVIDd, LVMI, LAVI, TAPSE and LV-GLS (HR 1.02 95%CI [1.01-1.03], p = 0.007) whereas E/e' did not (HR 1.01 95%CI [0.98-1.04], p = 0.57). Furthermore, E/e'sr provided incremental prognostic information beyond a model including known risk factors: age, gender, total cholesterol, mean arterial pressure, heart rate, BMI, smoking status and E/e' (Harrell's C-statistics: 0.72 (0.68-0.77) vs 0.70 (0.66-0.75), p = 0.047). Conclusions: In HFrEF patients, E/e'sr provides independent and incremental prognostic information regarding all-cause mortality superior to E/e'

AB - Aims: The ratio of early mitral inflow velocity to global diastolic strain rate (E/e' sr) has recently emerged as a novel measure of left ventricular (LV) filling pressure. This new measure has demonstrated to have prognostic value superior to E/e'. This study aimed to investigate the prognostic value of E/e' sr in a large cohort of patients with heart failure with reduced ejection fraction (HFrEF) in relation to all-cause mortality. Methods: We retrospectively studied 897 HFrEF (mean age 66 +/- 12 years, 73% male, 59% ischemic cardiomyopathy) patients who underwent speckle tracking echocardiography where E/e' sr along with novel and conventional echocardiographic parameters were obtained. The primary endpoint was defined as all-cause mortality. Results: During follow-up (median: 40 months IQR: 22-57), 137 (15.3%) patients died. Both E/e'sr and E/e' were significantly associated with mortality (E/e' sr: HR 1.03 95%CI [1.02-1.04], p<0.001, per 0.10m increase) and (E/e': HR 1.04 95%CI [1.02-1.06], p = 0.001, per 1 unit increase). E/e' sr remained an independent predictor in a multivariable model after adjusting for age, gender, mean arterial pressure, heart rate, BMI, total cholesterol, diabetes mellitus, ischemic cardiomyopathy, LVEF, LVIDd, LVMI, LAVI, TAPSE and LV-GLS (HR 1.02 95%CI [1.01-1.03], p = 0.007) whereas E/e' did not (HR 1.01 95%CI [0.98-1.04], p = 0.57). Furthermore, E/e'sr provided incremental prognostic information beyond a model including known risk factors: age, gender, total cholesterol, mean arterial pressure, heart rate, BMI, smoking status and E/e' (Harrell's C-statistics: 0.72 (0.68-0.77) vs 0.70 (0.66-0.75), p = 0.047). Conclusions: In HFrEF patients, E/e'sr provides independent and incremental prognostic information regarding all-cause mortality superior to E/e'

KW - Two-dimensional speckle tracking echocardiographic

KW - early diastolic strain rate

KW - global longitudinal strain

KW - systolic heart failure

KW - HFrEF

KW - long-term outcome

KW - filling pressures

U2 - 10.1016/j.cardfail.2019.07.007

DO - 10.1016/j.cardfail.2019.07.007

M3 - Journal article

C2 - 31336135

VL - 25

SP - 877

EP - 885

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 11

ER -

ID: 232975591