Quantitation and gompertzian analysis of tumor growth
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Quantitation and gompertzian analysis of tumor growth. / Rygaard, K; Spang-Thomsen, M.
In: Breast Cancer Research and Treatment, Vol. 46, No. 2-3, 1998, p. 303-12.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Quantitation and gompertzian analysis of tumor growth
AU - Rygaard, K
AU - Spang-Thomsen, M
N1 - Keywords: Animals; Cell Division; Data Interpretation, Statistical; Disease Models, Animal; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Transplantation, Heterologous
PY - 1998
Y1 - 1998
N2 - Human tumor xenografts in immune-deficient animals are used to establish tumor growth curves and for studying the effect of experimental therapy on tumor growth. In this review we describe a method for making serial measurements of tumor size in the nude mouse model as well as methods used to transform the experimental data into useful growth curves. A transformed Gompertz function is used as the basis for calculating relevant parameters pertaining to tumor growth and response to therapy. The calculations are facilitated by use of a computer program which performs the necessary calculations and presents the growth data in graphic form.
AB - Human tumor xenografts in immune-deficient animals are used to establish tumor growth curves and for studying the effect of experimental therapy on tumor growth. In this review we describe a method for making serial measurements of tumor size in the nude mouse model as well as methods used to transform the experimental data into useful growth curves. A transformed Gompertz function is used as the basis for calculating relevant parameters pertaining to tumor growth and response to therapy. The calculations are facilitated by use of a computer program which performs the necessary calculations and presents the growth data in graphic form.
M3 - Journal article
C2 - 9478282
VL - 46
SP - 303
EP - 312
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2-3
ER -
ID: 12870087