Pretransplant endotrophin predicts delayed graft function after kidney transplantation
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Pretransplant endotrophin predicts delayed graft function after kidney transplantation. / Tepel, Martin; Alkaff, Firas F.; Kremer, Daan; Bakker, Stephan J.L.; Thaunat, Olivier; Nagarajah, Subagini; Saleh, Qais; Berger, Stefan P.; van den Born, Jacob; Krogstrup, Nicoline V.; Nielsen, Marie B.; Nørregaard, Rikke; Jespersen, Bente; Sparding, Nadja; Genovese, Federica; Karsdal, Morten A.; Rasmussen, Daniel G.K.
In: Scientific Reports, Vol. 12, No. 1, 4079, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pretransplant endotrophin predicts delayed graft function after kidney transplantation
AU - Tepel, Martin
AU - Alkaff, Firas F.
AU - Kremer, Daan
AU - Bakker, Stephan J.L.
AU - Thaunat, Olivier
AU - Nagarajah, Subagini
AU - Saleh, Qais
AU - Berger, Stefan P.
AU - van den Born, Jacob
AU - Krogstrup, Nicoline V.
AU - Nielsen, Marie B.
AU - Nørregaard, Rikke
AU - Jespersen, Bente
AU - Sparding, Nadja
AU - Genovese, Federica
AU - Karsdal, Morten A.
AU - Rasmussen, Daniel G.K.
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Delayed graft function after kidney transplantation is common and increases morbidity and health care costs. There is evidence that endotrophin, a specific fragment of pro-collagen type VI, promotes the inflammatory response in kidney diseases. We tested the hypothesis that pretransplant endotrophin in kidney transplant recipients may be associated with the risk of delayed graft function. Pretransplant plasma endotrophin was assessed using an enzyme-linked immunosorbent assay in three independent cohorts with 806 kidney transplant recipients. The primary outcome was delayed graft function, i.e., the necessity of at least one dialysis session within one-week posttransplant. In the discovery cohort median pretransplant plasma endotrophin was higher in 32 recipients (12%) who showed delayed graft function when compared to 225 recipients without delayed graft function (58.4 ng/mL [IQR 33.4–69.0]; N = 32; vs. 39.5 ng/mL [IQR 30.6–54.5]; N = 225; P = 0.009). Multivariable logistic regression, fully adjusted for confounders showed, that pretransplant plasma endotrophin as a continuous variable was independently associated with delayed graft function in both validation cohorts, odds ratio 2.09 [95% CI 1.30–3.36] and 2.06 [95% CI 1.43–2.97]. Pretransplant plasma endotrophin, a potentially modifiable factor, was independently associated with increased risk of delayed graft function and may be a new avenue for therapeutic interventions.
AB - Delayed graft function after kidney transplantation is common and increases morbidity and health care costs. There is evidence that endotrophin, a specific fragment of pro-collagen type VI, promotes the inflammatory response in kidney diseases. We tested the hypothesis that pretransplant endotrophin in kidney transplant recipients may be associated with the risk of delayed graft function. Pretransplant plasma endotrophin was assessed using an enzyme-linked immunosorbent assay in three independent cohorts with 806 kidney transplant recipients. The primary outcome was delayed graft function, i.e., the necessity of at least one dialysis session within one-week posttransplant. In the discovery cohort median pretransplant plasma endotrophin was higher in 32 recipients (12%) who showed delayed graft function when compared to 225 recipients without delayed graft function (58.4 ng/mL [IQR 33.4–69.0]; N = 32; vs. 39.5 ng/mL [IQR 30.6–54.5]; N = 225; P = 0.009). Multivariable logistic regression, fully adjusted for confounders showed, that pretransplant plasma endotrophin as a continuous variable was independently associated with delayed graft function in both validation cohorts, odds ratio 2.09 [95% CI 1.30–3.36] and 2.06 [95% CI 1.43–2.97]. Pretransplant plasma endotrophin, a potentially modifiable factor, was independently associated with increased risk of delayed graft function and may be a new avenue for therapeutic interventions.
UR - http://www.scopus.com/inward/record.url?scp=85126076401&partnerID=8YFLogxK
U2 - 10.1038/s41598-022-07645-y
DO - 10.1038/s41598-022-07645-y
M3 - Journal article
C2 - 35260630
AN - SCOPUS:85126076401
VL - 12
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 4079
ER -
ID: 311114806