Phylogenetic analysis in a recent controlled outbreak of Crimean-Congo haemorrhagic fever in the south of Iran, December 2008
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Phylogenetic analysis in a recent controlled outbreak of Crimean-Congo haemorrhagic fever in the south of Iran, December 2008. / Chinikar, S; Ghiasi, Seyed Mojtaba; Mojtaba Ghiasi, S; Moradi, M; Goya, M M; Reza Shirzadi, M; Zeinali, M; Mostafavi, E; Pourahmad, M; Haeri, A.
In: Eurosurveillance (Online Edition), Vol. 15, No. 47, 25.11.2010.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Phylogenetic analysis in a recent controlled outbreak of Crimean-Congo haemorrhagic fever in the south of Iran, December 2008
AU - Chinikar, S
AU - Ghiasi, Seyed Mojtaba
AU - Mojtaba Ghiasi, S
AU - Moradi, M
AU - Goya, M M
AU - Reza Shirzadi, M
AU - Zeinali, M
AU - Mostafavi, E
AU - Pourahmad, M
AU - Haeri, A
PY - 2010/11/25
Y1 - 2010/11/25
N2 - Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease with a high mortality rate in humans. The CCHF virus is transmitted to humans through the bite of Ixodid ticks or contact with blood or tissues of CCHF patients or infected livestock. In December 2008, a re-emerging outbreak of CCHF occurred in the southern part of Iran. Five people were hospitalised with sudden fever and haemorrhaging, and CCHF was confirmed by RT-PCR and serological assays. One of the cases had a fulminant course and died. Livestock was identified as the source of infection; all animals in the incriminated herd were serologically analysed and more than half of them were positive for CCHFV. We demonstrated that two routes of transmission played a role in this outbreak: contact with tissue and blood of infected livestock, and nosocomial transmission. Phylogenetic analyses helped to identify the origin of this transmission. This outbreak should be considered as a warning for the national CCHF surveillance system to avoid further outbreaks through robust prevention and control programmes.
AB - Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease with a high mortality rate in humans. The CCHF virus is transmitted to humans through the bite of Ixodid ticks or contact with blood or tissues of CCHF patients or infected livestock. In December 2008, a re-emerging outbreak of CCHF occurred in the southern part of Iran. Five people were hospitalised with sudden fever and haemorrhaging, and CCHF was confirmed by RT-PCR and serological assays. One of the cases had a fulminant course and died. Livestock was identified as the source of infection; all animals in the incriminated herd were serologically analysed and more than half of them were positive for CCHFV. We demonstrated that two routes of transmission played a role in this outbreak: contact with tissue and blood of infected livestock, and nosocomial transmission. Phylogenetic analyses helped to identify the origin of this transmission. This outbreak should be considered as a warning for the national CCHF surveillance system to avoid further outbreaks through robust prevention and control programmes.
KW - Animals
KW - Antibodies, Viral
KW - Cross Infection
KW - Disease Outbreaks
KW - Hemorrhagic Fever Virus, Crimean-Congo
KW - Hemorrhagic Fever, Crimean
KW - Humans
KW - Iran
KW - Livestock
KW - RNA, Viral
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Serologic Tests
KW - Ticks
KW - Zoonoses
M3 - Journal article
C2 - 21144440
VL - 15
JO - Eurosurveillance
JF - Eurosurveillance
SN - 1025-496X
IS - 47
ER -
ID: 132430075