p53 mediates density-dependent growth arrest

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p53 mediates density-dependent growth arrest. / Meerson, A; Milyavsky, M; Rotter, M.

In: FEBS Letters, Vol. 559, No. 1-3, 13.02.2004, p. 152-158.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Meerson, A, Milyavsky, M & Rotter, M 2004, 'p53 mediates density-dependent growth arrest', FEBS Letters, vol. 559, no. 1-3, pp. 152-158. https://doi.org/10.1016/S0014-5793(04)00027-4

APA

Meerson, A., Milyavsky, M., & Rotter, M. (2004). p53 mediates density-dependent growth arrest. FEBS Letters, 559(1-3), 152-158. https://doi.org/10.1016/S0014-5793(04)00027-4

Vancouver

Meerson A, Milyavsky M, Rotter M. p53 mediates density-dependent growth arrest. FEBS Letters. 2004 Feb 13;559(1-3):152-158. https://doi.org/10.1016/S0014-5793(04)00027-4

Author

Meerson, A ; Milyavsky, M ; Rotter, M. / p53 mediates density-dependent growth arrest. In: FEBS Letters. 2004 ; Vol. 559, No. 1-3. pp. 152-158.

Bibtex

@article{b2850a760da649aa937e3e872795e974,
title = "p53 mediates density-dependent growth arrest",
abstract = "While the stress-response-associated importance of the p53 tumor suppressor is well established, recent studies have also linked p53 with several basic parameters in the normal behavior of cells. Here, we present evidence that basal p53 expression in WI38 human embryonic lung fibroblasts restricts growth rate and mediates density-dependent inhibition of growth and the associated G1 phase arrest of the cell cycle by affecting the density-dependent regulation of p16/INK4a. Additionally, we show that prolonged culturing of hTert-immortalized WI38 cells leads to a loss of density-dependent growth inhibition that correlates with p27/KIP deregulation as well as the previously shown INK4a locus silencing, and to an onset of contact-induced, p53-dependent cell death. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
keywords = "p53, p16/INK4a, contact inhibition, density-dependent, CONTACT-INHIBITION, BETA-CATENIN, CELL-GROWTH, EXPRESSION, LOCALIZATION, FIBROBLASTS, ELEMENTS",
author = "A Meerson and M Milyavsky and M. Rotter",
year = "2004",
month = feb,
day = "13",
doi = "10.1016/S0014-5793(04)00027-4",
language = "English",
volume = "559",
pages = "152--158",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1-3",

}

RIS

TY - JOUR

T1 - p53 mediates density-dependent growth arrest

AU - Meerson, A

AU - Milyavsky, M

AU - Rotter, M.

PY - 2004/2/13

Y1 - 2004/2/13

N2 - While the stress-response-associated importance of the p53 tumor suppressor is well established, recent studies have also linked p53 with several basic parameters in the normal behavior of cells. Here, we present evidence that basal p53 expression in WI38 human embryonic lung fibroblasts restricts growth rate and mediates density-dependent inhibition of growth and the associated G1 phase arrest of the cell cycle by affecting the density-dependent regulation of p16/INK4a. Additionally, we show that prolonged culturing of hTert-immortalized WI38 cells leads to a loss of density-dependent growth inhibition that correlates with p27/KIP deregulation as well as the previously shown INK4a locus silencing, and to an onset of contact-induced, p53-dependent cell death. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - While the stress-response-associated importance of the p53 tumor suppressor is well established, recent studies have also linked p53 with several basic parameters in the normal behavior of cells. Here, we present evidence that basal p53 expression in WI38 human embryonic lung fibroblasts restricts growth rate and mediates density-dependent inhibition of growth and the associated G1 phase arrest of the cell cycle by affecting the density-dependent regulation of p16/INK4a. Additionally, we show that prolonged culturing of hTert-immortalized WI38 cells leads to a loss of density-dependent growth inhibition that correlates with p27/KIP deregulation as well as the previously shown INK4a locus silencing, and to an onset of contact-induced, p53-dependent cell death. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - p53

KW - p16/INK4a

KW - contact inhibition

KW - density-dependent

KW - CONTACT-INHIBITION

KW - BETA-CATENIN

KW - CELL-GROWTH

KW - EXPRESSION

KW - LOCALIZATION

KW - FIBROBLASTS

KW - ELEMENTS

U2 - 10.1016/S0014-5793(04)00027-4

DO - 10.1016/S0014-5793(04)00027-4

M3 - Journal article

VL - 559

SP - 152

EP - 158

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 1-3

ER -

ID: 289311103