Organism-wide, cell-type-specific secretome mapping of exercise training in mice

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Organism-wide, cell-type-specific secretome mapping of exercise training in mice. / Wei, Wei; Riley, Nicholas M.; Lyu, Xuchao; Shen, Xiaotao; Guo, Jing; Raun, Steffen H.; Zhao, Meng; Moya-Garzon, Maria Dolores; Basu, Himanish; Sheng-Hwa Tung, Alan; Li, Veronica L.; Huang, Wentao; Wiggenhorn, Amanda L.; Svensson, Katrin J.; Snyder, Michael P.; Bertozzi, Carolyn R.; Long, Jonathan Z.

In: Cell Metabolism, Vol. 35, No. 7, e11, 2023, p. 1261-1279.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wei, W, Riley, NM, Lyu, X, Shen, X, Guo, J, Raun, SH, Zhao, M, Moya-Garzon, MD, Basu, H, Sheng-Hwa Tung, A, Li, VL, Huang, W, Wiggenhorn, AL, Svensson, KJ, Snyder, MP, Bertozzi, CR & Long, JZ 2023, 'Organism-wide, cell-type-specific secretome mapping of exercise training in mice', Cell Metabolism, vol. 35, no. 7, e11, pp. 1261-1279. https://doi.org/10.1016/j.cmet.2023.04.011

APA

Wei, W., Riley, N. M., Lyu, X., Shen, X., Guo, J., Raun, S. H., Zhao, M., Moya-Garzon, M. D., Basu, H., Sheng-Hwa Tung, A., Li, V. L., Huang, W., Wiggenhorn, A. L., Svensson, K. J., Snyder, M. P., Bertozzi, C. R., & Long, J. Z. (2023). Organism-wide, cell-type-specific secretome mapping of exercise training in mice. Cell Metabolism, 35(7), 1261-1279. [e11]. https://doi.org/10.1016/j.cmet.2023.04.011

Vancouver

Wei W, Riley NM, Lyu X, Shen X, Guo J, Raun SH et al. Organism-wide, cell-type-specific secretome mapping of exercise training in mice. Cell Metabolism. 2023;35(7):1261-1279. e11. https://doi.org/10.1016/j.cmet.2023.04.011

Author

Wei, Wei ; Riley, Nicholas M. ; Lyu, Xuchao ; Shen, Xiaotao ; Guo, Jing ; Raun, Steffen H. ; Zhao, Meng ; Moya-Garzon, Maria Dolores ; Basu, Himanish ; Sheng-Hwa Tung, Alan ; Li, Veronica L. ; Huang, Wentao ; Wiggenhorn, Amanda L. ; Svensson, Katrin J. ; Snyder, Michael P. ; Bertozzi, Carolyn R. ; Long, Jonathan Z. / Organism-wide, cell-type-specific secretome mapping of exercise training in mice. In: Cell Metabolism. 2023 ; Vol. 35, No. 7. pp. 1261-1279.

Bibtex

@article{146eef5725a04b74916fccfeea1e681e,
title = "Organism-wide, cell-type-specific secretome mapping of exercise training in mice",
abstract = "There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.",
keywords = "cell type, CES2, energy metabolism, exercise, exercise performance, hepatokine, obesity, secretome, tissue crosstalk",
author = "Wei Wei and Riley, {Nicholas M.} and Xuchao Lyu and Xiaotao Shen and Jing Guo and Raun, {Steffen H.} and Meng Zhao and Moya-Garzon, {Maria Dolores} and Himanish Basu and {Sheng-Hwa Tung}, Alan and Li, {Veronica L.} and Wentao Huang and Wiggenhorn, {Amanda L.} and Svensson, {Katrin J.} and Snyder, {Michael P.} and Bertozzi, {Carolyn R.} and Long, {Jonathan Z.}",
note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",
year = "2023",
doi = "10.1016/j.cmet.2023.04.011",
language = "English",
volume = "35",
pages = "1261--1279",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Organism-wide, cell-type-specific secretome mapping of exercise training in mice

AU - Wei, Wei

AU - Riley, Nicholas M.

AU - Lyu, Xuchao

AU - Shen, Xiaotao

AU - Guo, Jing

AU - Raun, Steffen H.

AU - Zhao, Meng

AU - Moya-Garzon, Maria Dolores

AU - Basu, Himanish

AU - Sheng-Hwa Tung, Alan

AU - Li, Veronica L.

AU - Huang, Wentao

AU - Wiggenhorn, Amanda L.

AU - Svensson, Katrin J.

AU - Snyder, Michael P.

AU - Bertozzi, Carolyn R.

AU - Long, Jonathan Z.

N1 - Publisher Copyright: © 2023 Elsevier Inc.

PY - 2023

Y1 - 2023

N2 - There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.

AB - There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.

KW - cell type

KW - CES2

KW - energy metabolism

KW - exercise

KW - exercise performance

KW - hepatokine

KW - obesity

KW - secretome

KW - tissue crosstalk

UR - http://www.scopus.com/inward/record.url?scp=85163155389&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2023.04.011

DO - 10.1016/j.cmet.2023.04.011

M3 - Journal article

C2 - 37141889

AN - SCOPUS:85163155389

VL - 35

SP - 1261

EP - 1279

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 7

M1 - e11

ER -

ID: 358968199