Non-invasive study of nerve fibres using laser interference microscopy
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Non-invasive study of nerve fibres using laser interference microscopy. / Brazhe, Alexey; Brazhe, Nadezda; Rodionova, N N; Yusipovich, A I; Ignatyev, P S; Maksimov, G V; Mosekilde, Erik; Sosnovtseva, Olga.
In: Royal Society of London. Philosophical Transactions. Mathematical, Physical and Engineering Sciences, Vol. 366, No. 1880, 13.10.2008, p. 3463-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Non-invasive study of nerve fibres using laser interference microscopy
AU - Brazhe, Alexey
AU - Brazhe, Nadezda
AU - Rodionova, N N
AU - Yusipovich, A I
AU - Ignatyev, P S
AU - Maksimov, G V
AU - Mosekilde, Erik
AU - Sosnovtseva, Olga
PY - 2008/10/13
Y1 - 2008/10/13
N2 - This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.
AB - This paper presents the results of a laser interference microscopy study of the morphology and dynamical properties of myelinated nerve fibres. We describe the principles of operation of the phase-modulated laser interference microscope and show how this novel technique allows us to obtain information non-invasively about the internal structure of different regions of a nerve fibre. We also analyse the temporal variations in the internal optical properties in order to detect the rhythmic activity in the nerve fibre at different time scales and to shed light on the underlying biological processes. We observe pronounced frequencies in the dynamics of the optical properties and suggest that the oscillatory modes have similar origin in different regions, but different strengths and mutual modulation properties.
KW - Animals
KW - Equipment Design
KW - Humans
KW - Lasers
KW - Light
KW - Microscopy, Confocal
KW - Microscopy, Interference
KW - Models, Neurological
KW - Models, Statistical
KW - Myelin Sheath
KW - Nerve Fibers
KW - Neurons
KW - Oscillometry
KW - Time Factors
U2 - 10.1098/rsta.2008.0107
DO - 10.1098/rsta.2008.0107
M3 - Journal article
C2 - 18644770
VL - 366
SP - 3463
EP - 3481
JO - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
JF - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
SN - 1364-503X
IS - 1880
ER -
ID: 33812380