Neurocan is dispensable for brain development.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Neurocan is dispensable for brain development. / Zhou, X H; Brakebusch, C; Matthies, H; Oohashi, T; Hirsch, E; Moser, M; Krug, M; Seidenbecher, C I; Boeckers, T M; Rauch, U; Buettner, R; Gundelfinger, E D; Fässler, R.

In: Molecular and Cellular Biology, Vol. 21, No. 17, 2001, p. 5970-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhou, XH, Brakebusch, C, Matthies, H, Oohashi, T, Hirsch, E, Moser, M, Krug, M, Seidenbecher, CI, Boeckers, TM, Rauch, U, Buettner, R, Gundelfinger, ED & Fässler, R 2001, 'Neurocan is dispensable for brain development.', Molecular and Cellular Biology, vol. 21, no. 17, pp. 5970-8.

APA

Zhou, X. H., Brakebusch, C., Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., Buettner, R., Gundelfinger, E. D., & Fässler, R. (2001). Neurocan is dispensable for brain development. Molecular and Cellular Biology, 21(17), 5970-8.

Vancouver

Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M et al. Neurocan is dispensable for brain development. Molecular and Cellular Biology. 2001;21(17):5970-8.

Author

Zhou, X H ; Brakebusch, C ; Matthies, H ; Oohashi, T ; Hirsch, E ; Moser, M ; Krug, M ; Seidenbecher, C I ; Boeckers, T M ; Rauch, U ; Buettner, R ; Gundelfinger, E D ; Fässler, R. / Neurocan is dispensable for brain development. In: Molecular and Cellular Biology. 2001 ; Vol. 21, No. 17. pp. 5970-8.

Bibtex

@article{974d5090589911dd8d9f000ea68e967b,
title = "Neurocan is dispensable for brain development.",
abstract = "Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.",
author = "Zhou, {X H} and C Brakebusch and H Matthies and T Oohashi and E Hirsch and M Moser and M Krug and Seidenbecher, {C I} and Boeckers, {T M} and U Rauch and R Buettner and Gundelfinger, {E D} and R F{\"a}ssler",
note = "Keywords: Animals; Brain; Extracellular Matrix Proteins; Gene Expression Regulation, Developmental; Hippocampus; Lectins, C-Type; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Proteochondroitin Sulfates; Synapses; Tenascin; Up-Regulation",
year = "2001",
language = "English",
volume = "21",
pages = "5970--8",
journal = "Molecular and Cellular Biology",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "17",

}

RIS

TY - JOUR

T1 - Neurocan is dispensable for brain development.

AU - Zhou, X H

AU - Brakebusch, C

AU - Matthies, H

AU - Oohashi, T

AU - Hirsch, E

AU - Moser, M

AU - Krug, M

AU - Seidenbecher, C I

AU - Boeckers, T M

AU - Rauch, U

AU - Buettner, R

AU - Gundelfinger, E D

AU - Fässler, R

N1 - Keywords: Animals; Brain; Extracellular Matrix Proteins; Gene Expression Regulation, Developmental; Hippocampus; Lectins, C-Type; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Proteochondroitin Sulfates; Synapses; Tenascin; Up-Regulation

PY - 2001

Y1 - 2001

N2 - Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.

AB - Neurocan is a component of the extracellular matrix in brain. Due to its inhibition of neuronal adhesion and outgrowth in vitro and its expression pattern in vivo it was suggested to play an important role in axon guidance and neurite growth. To study the role of neurocan in brain development we generated neurocan-deficient mice by targeted disruption of the neurocan gene. These mice are viable and fertile and have no obvious deficits in reproduction and general performance. Brain anatomy, morphology, and ultrastructure are similar to those of wild-type mice. Perineuronal nets surrounding neurons appear largely normal. Mild deficits in synaptic plasticity may exist, as maintenance of late-phase hippocampal long-term potentiation is reduced. These data indicate that neurocan has either a redundant or a more subtle function in the development of the brain.

M3 - Journal article

C2 - 11486035

VL - 21

SP - 5970

EP - 5978

JO - Molecular and Cellular Biology

JF - Molecular and Cellular Biology

SN - 0270-7306

IS - 17

ER -

ID: 5141637