Muscle metaboreflex control of the circulation during exercise

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Muscle metaboreflex control of the circulation during exercise. / Boushel, Robert Christopher.

In: Acta Physiologica (Print), Vol. 199, No. 4, 01.08.2010, p. 367-83.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Boushel, RC 2010, 'Muscle metaboreflex control of the circulation during exercise', Acta Physiologica (Print), vol. 199, no. 4, pp. 367-83. https://doi.org/10.1111/j.1748-1716.2010.02133.x

APA

Boushel, R. C. (2010). Muscle metaboreflex control of the circulation during exercise. Acta Physiologica (Print), 199(4), 367-83. https://doi.org/10.1111/j.1748-1716.2010.02133.x

Vancouver

Boushel RC. Muscle metaboreflex control of the circulation during exercise. Acta Physiologica (Print). 2010 Aug 1;199(4):367-83. https://doi.org/10.1111/j.1748-1716.2010.02133.x

Author

Boushel, Robert Christopher. / Muscle metaboreflex control of the circulation during exercise. In: Acta Physiologica (Print). 2010 ; Vol. 199, No. 4. pp. 367-83.

Bibtex

@article{8d9d91e81db24098a0f6ccde45b02542,
title = "Muscle metaboreflex control of the circulation during exercise",
abstract = "This review covers the control of blood pressure, cardiac output and muscle blood flow by the muscle metaboreflex which involves chemically sensitive nerves located in muscle parenchyma activated by metabolites accumulating in the muscle during contraction. The efferent response to metaboreflex activation is an increase in sympathetic nerve activity that constricts the systemic vasculature and also evokes parallel inotropic and chronotropic effects on the heart to increase cardiac output. The metaboreflex elicits a significant blood pressure elevating response during exercise and functions to redistribute blood flow and blood volume. Regional specificity in the efferent response to the metaboreflex activated from either the leg or the arm is seen in the balance between signals for vasoconstriction to curtail blood flow and signals to increase cardiac output. The metaboreflex has dual functions. It can both elevate and decrease muscle blood flow depending on (1) the intensity and mode of contraction, (2) the limb in which the reflex is evoked, (3) the strength of the signal defined by the muscle mass, (4) the extent to which blood flow is redistributed from inactive vascular beds to increase central blood volume and (5) the extent to which cardiac output can be increased.",
keywords = "Animals, Blood Pressure, Cardiac Output, Heart, Heart Rate, Hemodynamics, Humans, Leg, Muscle, Skeletal, Reflex, Regional Blood Flow, Sympathetic Nervous System, Vasoconstriction",
author = "Boushel, {Robert Christopher}",
year = "2010",
month = aug,
day = "1",
doi = "10.1111/j.1748-1716.2010.02133.x",
language = "English",
volume = "199",
pages = "367--83",
journal = "Acta Physiologica",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Muscle metaboreflex control of the circulation during exercise

AU - Boushel, Robert Christopher

PY - 2010/8/1

Y1 - 2010/8/1

N2 - This review covers the control of blood pressure, cardiac output and muscle blood flow by the muscle metaboreflex which involves chemically sensitive nerves located in muscle parenchyma activated by metabolites accumulating in the muscle during contraction. The efferent response to metaboreflex activation is an increase in sympathetic nerve activity that constricts the systemic vasculature and also evokes parallel inotropic and chronotropic effects on the heart to increase cardiac output. The metaboreflex elicits a significant blood pressure elevating response during exercise and functions to redistribute blood flow and blood volume. Regional specificity in the efferent response to the metaboreflex activated from either the leg or the arm is seen in the balance between signals for vasoconstriction to curtail blood flow and signals to increase cardiac output. The metaboreflex has dual functions. It can both elevate and decrease muscle blood flow depending on (1) the intensity and mode of contraction, (2) the limb in which the reflex is evoked, (3) the strength of the signal defined by the muscle mass, (4) the extent to which blood flow is redistributed from inactive vascular beds to increase central blood volume and (5) the extent to which cardiac output can be increased.

AB - This review covers the control of blood pressure, cardiac output and muscle blood flow by the muscle metaboreflex which involves chemically sensitive nerves located in muscle parenchyma activated by metabolites accumulating in the muscle during contraction. The efferent response to metaboreflex activation is an increase in sympathetic nerve activity that constricts the systemic vasculature and also evokes parallel inotropic and chronotropic effects on the heart to increase cardiac output. The metaboreflex elicits a significant blood pressure elevating response during exercise and functions to redistribute blood flow and blood volume. Regional specificity in the efferent response to the metaboreflex activated from either the leg or the arm is seen in the balance between signals for vasoconstriction to curtail blood flow and signals to increase cardiac output. The metaboreflex has dual functions. It can both elevate and decrease muscle blood flow depending on (1) the intensity and mode of contraction, (2) the limb in which the reflex is evoked, (3) the strength of the signal defined by the muscle mass, (4) the extent to which blood flow is redistributed from inactive vascular beds to increase central blood volume and (5) the extent to which cardiac output can be increased.

KW - Animals

KW - Blood Pressure

KW - Cardiac Output

KW - Heart

KW - Heart Rate

KW - Hemodynamics

KW - Humans

KW - Leg

KW - Muscle, Skeletal

KW - Reflex

KW - Regional Blood Flow

KW - Sympathetic Nervous System

KW - Vasoconstriction

U2 - 10.1111/j.1748-1716.2010.02133.x

DO - 10.1111/j.1748-1716.2010.02133.x

M3 - Journal article

C2 - 20353495

VL - 199

SP - 367

EP - 383

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 4

ER -

ID: 33815906