Muscle after spinal cord injury

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Muscle after spinal cord injury. / Biering-Sørensen, Bo; Kristensen, Ida Bruun; Kjaer, Michael; Biering-Sørensen, Fin.

In: Muscle & Nerve, Vol. 40, No. 4, 2009, p. 499-519.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Biering-Sørensen, B, Kristensen, IB, Kjaer, M & Biering-Sørensen, F 2009, 'Muscle after spinal cord injury', Muscle & Nerve, vol. 40, no. 4, pp. 499-519. https://doi.org/10.1002/mus.21391

APA

Biering-Sørensen, B., Kristensen, I. B., Kjaer, M., & Biering-Sørensen, F. (2009). Muscle after spinal cord injury. Muscle & Nerve, 40(4), 499-519. https://doi.org/10.1002/mus.21391

Vancouver

Biering-Sørensen B, Kristensen IB, Kjaer M, Biering-Sørensen F. Muscle after spinal cord injury. Muscle & Nerve. 2009;40(4):499-519. https://doi.org/10.1002/mus.21391

Author

Biering-Sørensen, Bo ; Kristensen, Ida Bruun ; Kjaer, Michael ; Biering-Sørensen, Fin. / Muscle after spinal cord injury. In: Muscle & Nerve. 2009 ; Vol. 40, No. 4. pp. 499-519.

Bibtex

@article{66417e30359d11df8ed1000ea68e967b,
title = "Muscle after spinal cord injury",
abstract = "The morphological and contractile changes of muscles below the level of the lesion after spinal cord injury (SCI) are dramatic. In humans with SCI, a fiber-type transformation away from type I begins 4-7 months post-SCI and reaches a new steady state with predominantly fast glycolytic IIX fibers years after the injury. There is a progressive drop in the proportion of slow myosin heavy chain (MHC) isoform fibers and a rise in the proportion of fibers that coexpress both the fast and slow MHC isoforms. The oxidative enzymatic activity starts to decline after the first few months post-SCI. Muscles from individuals with chronic SCI show less resistance to fatigue, and the speed-related contractile properties change, becoming faster. These findings are also present in animals. Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis.",
author = "Bo Biering-S{\o}rensen and Kristensen, {Ida Bruun} and Michael Kjaer and Fin Biering-S{\o}rensen",
note = "Keywords: Adenosine Triphosphatases; Animals; Cats; Disease Models, Animal; Female; Glycolysis; Humans; Male; Mice; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Oxidation-Reduction; Rabbits; Rats; Regional Blood Flow; Spinal Cord Injuries Times Cited: 0ReviewEnglishBiering-Sorensen, BCopenhagen Univ Hosp, Clin Spinal Cord Injuries, Ctr Neurosci, Rigshosp, Havnevej 25, DK-3100 Hornbaek, DenmarkCited References Count: 106506SAJOHN WILEY & SONS INC111 RIVER ST, HOBOKEN, NJ 07030 USAHOBOKEN",
year = "2009",
doi = "10.1002/mus.21391",
language = "English",
volume = "40",
pages = "499--519",
journal = "Muscle & Nerve",
issn = "0148-639X",
publisher = "JohnWiley & Sons, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Muscle after spinal cord injury

AU - Biering-Sørensen, Bo

AU - Kristensen, Ida Bruun

AU - Kjaer, Michael

AU - Biering-Sørensen, Fin

N1 - Keywords: Adenosine Triphosphatases; Animals; Cats; Disease Models, Animal; Female; Glycolysis; Humans; Male; Mice; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Oxidation-Reduction; Rabbits; Rats; Regional Blood Flow; Spinal Cord Injuries Times Cited: 0ReviewEnglishBiering-Sorensen, BCopenhagen Univ Hosp, Clin Spinal Cord Injuries, Ctr Neurosci, Rigshosp, Havnevej 25, DK-3100 Hornbaek, DenmarkCited References Count: 106506SAJOHN WILEY & SONS INC111 RIVER ST, HOBOKEN, NJ 07030 USAHOBOKEN

PY - 2009

Y1 - 2009

N2 - The morphological and contractile changes of muscles below the level of the lesion after spinal cord injury (SCI) are dramatic. In humans with SCI, a fiber-type transformation away from type I begins 4-7 months post-SCI and reaches a new steady state with predominantly fast glycolytic IIX fibers years after the injury. There is a progressive drop in the proportion of slow myosin heavy chain (MHC) isoform fibers and a rise in the proportion of fibers that coexpress both the fast and slow MHC isoforms. The oxidative enzymatic activity starts to decline after the first few months post-SCI. Muscles from individuals with chronic SCI show less resistance to fatigue, and the speed-related contractile properties change, becoming faster. These findings are also present in animals. Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis.

AB - The morphological and contractile changes of muscles below the level of the lesion after spinal cord injury (SCI) are dramatic. In humans with SCI, a fiber-type transformation away from type I begins 4-7 months post-SCI and reaches a new steady state with predominantly fast glycolytic IIX fibers years after the injury. There is a progressive drop in the proportion of slow myosin heavy chain (MHC) isoform fibers and a rise in the proportion of fibers that coexpress both the fast and slow MHC isoforms. The oxidative enzymatic activity starts to decline after the first few months post-SCI. Muscles from individuals with chronic SCI show less resistance to fatigue, and the speed-related contractile properties change, becoming faster. These findings are also present in animals. Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis.

U2 - 10.1002/mus.21391

DO - 10.1002/mus.21391

M3 - Journal article

C2 - 19705475

VL - 40

SP - 499

EP - 519

JO - Muscle & Nerve

JF - Muscle & Nerve

SN - 0148-639X

IS - 4

ER -

ID: 18764148