Multiple Targets for Oxysterols in Their Regulation of the Immune System

Research output: Contribution to journal › Review › Research › peer-review

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Multiple Targets for Oxysterols in Their Regulation of the Immune System. / Reinmuth, Lisa; Hsiao, Cheng Chih; Hamann, Jörg; Rosenkilde, Mette; Mackrill, John.

In: Cells, Vol. 10, No. 8, 2078, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Reinmuth, L, Hsiao, CC, Hamann, J, Rosenkilde, M & Mackrill, J 2021, 'Multiple Targets for Oxysterols in Their Regulation of the Immune System', Cells, vol. 10, no. 8, 2078. https://doi.org/10.3390/cells10082078

APA

Reinmuth, L., Hsiao, C. C., Hamann, J., Rosenkilde, M., & Mackrill, J. (2021). Multiple Targets for Oxysterols in Their Regulation of the Immune System. Cells, 10(8), [2078]. https://doi.org/10.3390/cells10082078

Vancouver

Reinmuth L, Hsiao CC, Hamann J, Rosenkilde M, Mackrill J. Multiple Targets for Oxysterols in Their Regulation of the Immune System. Cells. 2021;10(8). 2078. https://doi.org/10.3390/cells10082078

Author

Reinmuth, Lisa ; Hsiao, Cheng Chih ; Hamann, Jörg ; Rosenkilde, Mette ; Mackrill, John. / Multiple Targets for Oxysterols in Their Regulation of the Immune System. In: Cells. 2021 ; Vol. 10, No. 8.

Bibtex

@article{9965abcffbe7448ba077decc85f144e8,
title = "Multiple Targets for Oxysterols in Their Regulation of the Immune System",
abstract = "Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system. In contrast to effects that are mediated through nuclear receptors or by epigenetic mechanism, which take tens of minutes to occur, changes in the activities of cell-surface receptors caused by oxysterols can be extremely rapid, often taking place within subsecond timescales. Such cell-surface receptor effects of oxysterols allow for the regulation of fast cellular processes, such as motility, secretion and endocytosis. These cellular processes play critical roles in both the innate and adaptive immune systems. This review will survey the two broad classes of cell-surface receptors for oxysterols (G-protein coupled receptors (GPCRs) and ion channels), the mechanisms by which cholesterol oxidation products act on them, and their presence and functions in the different cell types of the immune system. Overall, this review will highlight the potential of oxysterols, synthetic derivatives and their receptors for physiological and therapeutic modulation of the immune system.",
keywords = "autoimmunity, immune response, infectious diseases, inflammation, ion channels, oxysterols, pharmacology, structure-function",
author = "Lisa Reinmuth and Hsiao, {Cheng Chih} and J{\"o}rg Hamann and Mette Rosenkilde and John Mackrill",
year = "2021",
doi = "10.3390/cells10082078",
language = "English",
volume = "10",
journal = "Cells",
issn = "2073-4409",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - Multiple Targets for Oxysterols in Their Regulation of the Immune System

AU - Reinmuth, Lisa

AU - Hsiao, Cheng Chih

AU - Hamann, Jörg

AU - Rosenkilde, Mette

AU - Mackrill, John

PY - 2021

Y1 - 2021

N2 - Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system. In contrast to effects that are mediated through nuclear receptors or by epigenetic mechanism, which take tens of minutes to occur, changes in the activities of cell-surface receptors caused by oxysterols can be extremely rapid, often taking place within subsecond timescales. Such cell-surface receptor effects of oxysterols allow for the regulation of fast cellular processes, such as motility, secretion and endocytosis. These cellular processes play critical roles in both the innate and adaptive immune systems. This review will survey the two broad classes of cell-surface receptors for oxysterols (G-protein coupled receptors (GPCRs) and ion channels), the mechanisms by which cholesterol oxidation products act on them, and their presence and functions in the different cell types of the immune system. Overall, this review will highlight the potential of oxysterols, synthetic derivatives and their receptors for physiological and therapeutic modulation of the immune system.

AB - Oxysterols, or cholesterol oxidation products, are naturally occurring lipids which regulate the physiology of cells, including those of the immune system. In contrast to effects that are mediated through nuclear receptors or by epigenetic mechanism, which take tens of minutes to occur, changes in the activities of cell-surface receptors caused by oxysterols can be extremely rapid, often taking place within subsecond timescales. Such cell-surface receptor effects of oxysterols allow for the regulation of fast cellular processes, such as motility, secretion and endocytosis. These cellular processes play critical roles in both the innate and adaptive immune systems. This review will survey the two broad classes of cell-surface receptors for oxysterols (G-protein coupled receptors (GPCRs) and ion channels), the mechanisms by which cholesterol oxidation products act on them, and their presence and functions in the different cell types of the immune system. Overall, this review will highlight the potential of oxysterols, synthetic derivatives and their receptors for physiological and therapeutic modulation of the immune system.

KW - autoimmunity

KW - immune response

KW - infectious diseases

KW - inflammation

KW - ion channels

KW - oxysterols

KW - pharmacology

KW - structure-function

UR - http://www.scopus.com/inward/record.url?scp=85115158306&partnerID=8YFLogxK

U2 - 10.3390/cells10082078

DO - 10.3390/cells10082078

M3 - Review

C2 - 34440846

AN - SCOPUS:85115158306

VL - 10

JO - Cells

JF - Cells

SN - 2073-4409

IS - 8

M1 - 2078

ER -

ID: 281110615