MR-proANP measured at admission is associated with incident atrial fibrillation in STEMI patients
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MR-proANP measured at admission is associated with incident atrial fibrillation in STEMI patients. / Wegener, Alma; Modin, Daniel; Pedersen, Sune; Lindberg, Soren; Pareek, Manan; Iversen, Kasper; Jespersen, Thomas; Gislason, Gunnar; Biering-Sorensen, Tor.
In: Heart and Vessels, Vol. 37, 2022, p. 1906–1913.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - MR-proANP measured at admission is associated with incident atrial fibrillation in STEMI patients
AU - Wegener, Alma
AU - Modin, Daniel
AU - Pedersen, Sune
AU - Lindberg, Soren
AU - Pareek, Manan
AU - Iversen, Kasper
AU - Jespersen, Thomas
AU - Gislason, Gunnar
AU - Biering-Sorensen, Tor
PY - 2022
Y1 - 2022
N2 - Atrial fibrillation (AF) is common following ST-segment elevation myocardial infarction (STEMI). Increased blood levels of mid regional pro atrial natriuretic peptide (MR-proANP) have been associated with a greater risk of incident AF. However, knowledge of the value of MR-proANP in predicting incident AF after STEMI is sparse. To assess whether MR-proANP measured at admission is associated with development of incident AF in patients with STEMI. 673 STEMI patients with no history of AF treated with primary percutaneous coronary intervention (pPCI) were prospectively enrolled from September 2006 to December 2008. Blood samples were drawn before the procedure. MR-proANP was measured by an automated processing assay. End point was incident AF. Median follow-up time was 5.5 years (interquartile-range 4.7-6.0), during which 63 patients developed AF. In a multivariable Cox regression model adjusted for relevant clinical and biochemical variables, MR-proANP was significantly associated with the development of AF (HR 1.18 per 100 pmol, 95% CI 1.11-1.28, p < 0.001). In a subgroup of patients who underwent echocardiography (N = 360), MR-proANP remained significantly associated with the development of AF (HR 1.39 per 100 pmol, 95% CI 1.13-1.71, p = 0.002) after adjusting for clinical and biochemical variables and left ventricular ejection fraction. When stratifying patients according to tertiles of MR-proANP, patients in the upper tertile displayed an 11 times greater risk of developing AF during follow-up as compared to patients in the lower tertile (HR 11.1, 95% CI 4.4-28.2, p < 0.001). Plasma MR-proANP measured at admission is an independent predictor of incident AF after STEMI.
AB - Atrial fibrillation (AF) is common following ST-segment elevation myocardial infarction (STEMI). Increased blood levels of mid regional pro atrial natriuretic peptide (MR-proANP) have been associated with a greater risk of incident AF. However, knowledge of the value of MR-proANP in predicting incident AF after STEMI is sparse. To assess whether MR-proANP measured at admission is associated with development of incident AF in patients with STEMI. 673 STEMI patients with no history of AF treated with primary percutaneous coronary intervention (pPCI) were prospectively enrolled from September 2006 to December 2008. Blood samples were drawn before the procedure. MR-proANP was measured by an automated processing assay. End point was incident AF. Median follow-up time was 5.5 years (interquartile-range 4.7-6.0), during which 63 patients developed AF. In a multivariable Cox regression model adjusted for relevant clinical and biochemical variables, MR-proANP was significantly associated with the development of AF (HR 1.18 per 100 pmol, 95% CI 1.11-1.28, p < 0.001). In a subgroup of patients who underwent echocardiography (N = 360), MR-proANP remained significantly associated with the development of AF (HR 1.39 per 100 pmol, 95% CI 1.13-1.71, p = 0.002) after adjusting for clinical and biochemical variables and left ventricular ejection fraction. When stratifying patients according to tertiles of MR-proANP, patients in the upper tertile displayed an 11 times greater risk of developing AF during follow-up as compared to patients in the lower tertile (HR 11.1, 95% CI 4.4-28.2, p < 0.001). Plasma MR-proANP measured at admission is an independent predictor of incident AF after STEMI.
KW - Acute myocardial infarction
KW - STEMI
KW - Atrial fibrillation
KW - MR-proANP
KW - Predictor
KW - PROATRIAL NATRIURETIC PEPTIDE
KW - ACUTE MYOCARDIAL-INFARCTION
KW - PREDICTION
KW - RISK
KW - BIOMARKERS
KW - MECHANISMS
KW - EVENTS
KW - STROKE
KW - MEN
U2 - 10.1007/s00380-022-02099-8
DO - 10.1007/s00380-022-02099-8
M3 - Journal article
C2 - 35648185
VL - 37
SP - 1906
EP - 1913
JO - Heart and Vessels
JF - Heart and Vessels
SN - 0910-8327
ER -
ID: 317440282