Mitochondrial dysfunction in calf muscles of patients with combined peripheral arterial disease and diabetes type 2
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Mitochondrial dysfunction in calf muscles of patients with combined peripheral arterial disease and diabetes type 2. / Lindegaard Pedersen, Brian; Bækgaard, Niels; Quistorff, Bjørn.
In: International Angiology, Vol. 36, No. 5, 10.2017, p. 482-495.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mitochondrial dysfunction in calf muscles of patients with combined peripheral arterial disease and diabetes type 2
AU - Lindegaard Pedersen, Brian
AU - Bækgaard, Niels
AU - Quistorff, Bjørn
PY - 2017/10
Y1 - 2017/10
N2 - BACKGROUND: This study elucidate the effects on muscle mitochondrial function in patients suffering from combined peripheral arterial disease (PAD) and type 2 diabetes (T2D) and the relation to patient symptoms and treatment.METHODS: Near Infra Red Spectroscopy (NIRS) calf muscle exercise tests were conducted on Forty subjects, 15 (PAD), 15 (PAD+T2D) and 10 healthy age matched controls (CTRL) recruited from the vascular outpatient clinic at Gentofte County Hospital, Denmark. Calf muscle biopsies (~ 80 mg) (Gastrocnemius and Anterior tibial muscles) were sampled and mitochondrial function tested applying high resolution oxygraphy on isolated muscle fibers.RESULTS: The NIRS exercise tests showed evidence of mitochondrial dysfunction in the PAD+T2D group by a longer recovery of the deoxygenation resulting from exercise in spite of a higher exercise oxygenation level compared to the PAD group. This was confirmed by a ~30% reduction in oxygen consumption in the muscle biopsy tests for the PAD+T2D compared to the PAD group (P<0.05). We claim that this mitochondrial dysfunction partly explains the ~30% reduction in tread mill walking distance for the PAD+T2D group observed in this study.CONCLUSIONS: These findings support the use of early surgical revascularization in the PAD+T2D group, in order to obtain better walking performance and probably reduced risk of permanent mitochondrial damage.
AB - BACKGROUND: This study elucidate the effects on muscle mitochondrial function in patients suffering from combined peripheral arterial disease (PAD) and type 2 diabetes (T2D) and the relation to patient symptoms and treatment.METHODS: Near Infra Red Spectroscopy (NIRS) calf muscle exercise tests were conducted on Forty subjects, 15 (PAD), 15 (PAD+T2D) and 10 healthy age matched controls (CTRL) recruited from the vascular outpatient clinic at Gentofte County Hospital, Denmark. Calf muscle biopsies (~ 80 mg) (Gastrocnemius and Anterior tibial muscles) were sampled and mitochondrial function tested applying high resolution oxygraphy on isolated muscle fibers.RESULTS: The NIRS exercise tests showed evidence of mitochondrial dysfunction in the PAD+T2D group by a longer recovery of the deoxygenation resulting from exercise in spite of a higher exercise oxygenation level compared to the PAD group. This was confirmed by a ~30% reduction in oxygen consumption in the muscle biopsy tests for the PAD+T2D compared to the PAD group (P<0.05). We claim that this mitochondrial dysfunction partly explains the ~30% reduction in tread mill walking distance for the PAD+T2D group observed in this study.CONCLUSIONS: These findings support the use of early surgical revascularization in the PAD+T2D group, in order to obtain better walking performance and probably reduced risk of permanent mitochondrial damage.
KW - Journal Article
U2 - 10.23736/S0392-9590.17.03824-X
DO - 10.23736/S0392-9590.17.03824-X
M3 - Journal article
C2 - 28291304
VL - 36
SP - 482
EP - 495
JO - International Angiology
JF - International Angiology
SN - 0392-9590
IS - 5
ER -
ID: 174398234