Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration
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Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration. / Larsen, Steen; Rabøl, R; Hansen, C N; Madsbad, S; Helge, J W; Dela, F.
In: Diabetologia, Vol. 55, No. 2, 2012, p. 443-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration
AU - Larsen, Steen
AU - Rabøl, R
AU - Hansen, C N
AU - Madsbad, S
AU - Helge, J W
AU - Dela, F
PY - 2012
Y1 - 2012
N2 - The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.
AB - The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.
KW - Blood Glucose
KW - Body Mass Index
KW - Case-Control Studies
KW - Cell Respiration
KW - Citrate (si)-Synthase
KW - Diabetes Mellitus, Type 2
KW - Electron Transport Complex I
KW - Hemoglobin A, Glycosylated
KW - Humans
KW - Hypoglycemic Agents
KW - Insulin
KW - Male
KW - Metformin
KW - Middle Aged
KW - Models, Biological
KW - Muscle, Skeletal
KW - Oxygen Consumption
KW - Sulfonylurea Compounds
U2 - 10.1007/s00125-011-2340-0
DO - 10.1007/s00125-011-2340-0
M3 - Journal article
C2 - 22009334
VL - 55
SP - 443
EP - 449
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 2
ER -
ID: 40176660