Mechanism of Proarrhythmic Effects of Potassium Channel Blockers
Research output: Contribution to journal › Journal article › Research › peer-review
Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.
Original language | English |
---|---|
Journal | Cardiac Electrophysiology Clinics |
Volume | 8 |
Issue number | 2 |
Pages (from-to) | 395-410 |
Number of pages | 16 |
ISSN | 1877-9182 |
DOIs | |
Publication status | Published - Jun 2016 |
- Action Potentials, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Heart Conduction System, Humans, Mice, Potassium Channel Blockers, Journal Article, Review
Research areas
ID: 173705335