Mechanism of Proarrhythmic Effects of Potassium Channel Blockers

Research output: Contribution to journal › Journal article › Research › peer-review

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Mechanism of Proarrhythmic Effects of Potassium Channel Blockers. / Skibsbye, Lasse; Ravens, Ursula.

In: Cardiac Electrophysiology Clinics, Vol. 8, No. 2, 06.2016, p. 395-410.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skibsbye, L & Ravens, U 2016, 'Mechanism of Proarrhythmic Effects of Potassium Channel Blockers', Cardiac Electrophysiology Clinics, vol. 8, no. 2, pp. 395-410. https://doi.org/10.1016/j.ccep.2016.02.004

APA

Skibsbye, L., & Ravens, U. (2016). Mechanism of Proarrhythmic Effects of Potassium Channel Blockers. Cardiac Electrophysiology Clinics, 8(2), 395-410. https://doi.org/10.1016/j.ccep.2016.02.004

Vancouver

Skibsbye L, Ravens U. Mechanism of Proarrhythmic Effects of Potassium Channel Blockers. Cardiac Electrophysiology Clinics. 2016 Jun;8(2):395-410. https://doi.org/10.1016/j.ccep.2016.02.004

Author

Skibsbye, Lasse ; Ravens, Ursula. / Mechanism of Proarrhythmic Effects of Potassium Channel Blockers. In: Cardiac Electrophysiology Clinics. 2016 ; Vol. 8, No. 2. pp. 395-410.

Bibtex

@article{90a1dc07afa44806a7ba20e3358e543c,
title = "Mechanism of Proarrhythmic Effects of Potassium Channel Blockers",
abstract = "Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.",
keywords = "Action Potentials, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Heart Conduction System, Humans, Mice, Potassium Channel Blockers, Journal Article, Review",
author = "Lasse Skibsbye and Ursula Ravens",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = jun,
doi = "10.1016/j.ccep.2016.02.004",
language = "English",
volume = "8",
pages = "395--410",
journal = "Cardiac Electrophysiology Clinics",
issn = "1877-9182",
publisher = "W.B.Saunders Co.",
number = "2",

}

RIS

TY - JOUR

T1 - Mechanism of Proarrhythmic Effects of Potassium Channel Blockers

AU - Skibsbye, Lasse

AU - Ravens, Ursula

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/6

Y1 - 2016/6

N2 - Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.

AB - Any disturbance of electrical impulse formation in the heart and of impulse conduction or action potential (AP) repolarization can lead to rhythm disorders. Potassium (K(+)) channels play a prominent role in the AP repolarization process. In this review we describe the causes and mechanisms of proarrhythmic effects that arise as a response to blockers of cardiac K(+) channels. The largest and chemically most diverse groups of compound targets are Kv11.1 (hERG) and Kv7.1 (KvLQT1) channels. Finally, the proarrhythmic propensity of atrial-selective K(+) blockers inhibiting Kv1.5, Kir3.1/3.4, SK, and K2P channels is discussed.

KW - Action Potentials

KW - Animals

KW - Anti-Arrhythmia Agents

KW - Arrhythmias, Cardiac

KW - Heart Conduction System

KW - Humans

KW - Mice

KW - Potassium Channel Blockers

KW - Journal Article

KW - Review

U2 - 10.1016/j.ccep.2016.02.004

DO - 10.1016/j.ccep.2016.02.004

M3 - Journal article

C2 - 27261830

VL - 8

SP - 395

EP - 410

JO - Cardiac Electrophysiology Clinics

JF - Cardiac Electrophysiology Clinics

SN - 1877-9182

IS - 2

ER -

ID: 173705335