Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies

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Standard

Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies. / Cardwell, Chris R; Stene, Lars C; Joner, Geir; Bulsara, Max K; Cinek, Ondrej; Rosenbauer, Joachim; Ludvigsson, Johnny; Jané, Mireia; Svensson, Jannet; Goldacre, Michael J; Waldhoer, Thomas; Jarosz-Chobot, Przemyslawa; Gimeno, Suely G A; Chuang, Lee-Ming; Parslow, Roger C; Wadsworth, Emma J K; Chetwynd, Amanda; Pozzilli, Paolo; Brigis, Girts; Urbonaite, Brone; Sipetic, Sandra; Schober, Edith; Devoti, Gabriele; Ionescu-Tirgoviste, Constantin; de Beaufort, Carine E; Stoyanov, Denka; Buschard, Karsten; Patterson, Chris C.

In: Diabetes, Vol. 59, No. 2, 2009, p. 486-94.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cardwell, CR, Stene, LC, Joner, G, Bulsara, MK, Cinek, O, Rosenbauer, J, Ludvigsson, J, Jané, M, Svensson, J, Goldacre, MJ, Waldhoer, T, Jarosz-Chobot, P, Gimeno, SGA, Chuang, L-M, Parslow, RC, Wadsworth, EJK, Chetwynd, A, Pozzilli, P, Brigis, G, Urbonaite, B, Sipetic, S, Schober, E, Devoti, G, Ionescu-Tirgoviste, C, de Beaufort, CE, Stoyanov, D, Buschard, K & Patterson, CC 2009, 'Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies', Diabetes, vol. 59, no. 2, pp. 486-94. https://doi.org/10.2337/db09-1166

APA

Cardwell, C. R., Stene, L. C., Joner, G., Bulsara, M. K., Cinek, O., Rosenbauer, J., Ludvigsson, J., Jané, M., Svensson, J., Goldacre, M. J., Waldhoer, T., Jarosz-Chobot, P., Gimeno, S. G. A., Chuang, L-M., Parslow, R. C., Wadsworth, E. J. K., Chetwynd, A., Pozzilli, P., Brigis, G., ... Patterson, C. C. (2009). Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies. Diabetes, 59(2), 486-94. https://doi.org/10.2337/db09-1166

Vancouver

Cardwell CR, Stene LC, Joner G, Bulsara MK, Cinek O, Rosenbauer J et al. Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies. Diabetes. 2009;59(2):486-94. https://doi.org/10.2337/db09-1166

Author

Cardwell, Chris R ; Stene, Lars C ; Joner, Geir ; Bulsara, Max K ; Cinek, Ondrej ; Rosenbauer, Joachim ; Ludvigsson, Johnny ; Jané, Mireia ; Svensson, Jannet ; Goldacre, Michael J ; Waldhoer, Thomas ; Jarosz-Chobot, Przemyslawa ; Gimeno, Suely G A ; Chuang, Lee-Ming ; Parslow, Roger C ; Wadsworth, Emma J K ; Chetwynd, Amanda ; Pozzilli, Paolo ; Brigis, Girts ; Urbonaite, Brone ; Sipetic, Sandra ; Schober, Edith ; Devoti, Gabriele ; Ionescu-Tirgoviste, Constantin ; de Beaufort, Carine E ; Stoyanov, Denka ; Buschard, Karsten ; Patterson, Chris C. / Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies. In: Diabetes. 2009 ; Vol. 59, No. 2. pp. 486-94.

Bibtex

@article{b2d8d2a0333d11df8ed1000ea68e967b,
title = "Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies",
abstract = "OBJECTIVE: The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS: Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS: Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I(2) = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS: There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.",
author = "Cardwell, {Chris R} and Stene, {Lars C} and Geir Joner and Bulsara, {Max K} and Ondrej Cinek and Joachim Rosenbauer and Johnny Ludvigsson and Mireia Jan{\'e} and Jannet Svensson and Goldacre, {Michael J} and Thomas Waldhoer and Przemyslawa Jarosz-Chobot and Gimeno, {Suely G A} and Lee-Ming Chuang and Parslow, {Roger C} and Wadsworth, {Emma J K} and Amanda Chetwynd and Paolo Pozzilli and Girts Brigis and Brone Urbonaite and Sandra Sipetic and Edith Schober and Gabriele Devoti and Constantin Ionescu-Tirgoviste and {de Beaufort}, {Carine E} and Denka Stoyanov and Karsten Buschard and Patterson, {Chris C}",
note = "Keywords: Adolescent; Adult; Age of Onset; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Diabetes Mellitus, Type 1; Female; Humans; Maternal Age; Meta-Analysis as Topic; Odds Ratio; Regression Analysis; Reproducibility of Results",
year = "2009",
doi = "10.2337/db09-1166",
language = "English",
volume = "59",
pages = "486--94",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "2",

}

RIS

TY - JOUR

T1 - Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies

AU - Cardwell, Chris R

AU - Stene, Lars C

AU - Joner, Geir

AU - Bulsara, Max K

AU - Cinek, Ondrej

AU - Rosenbauer, Joachim

AU - Ludvigsson, Johnny

AU - Jané, Mireia

AU - Svensson, Jannet

AU - Goldacre, Michael J

AU - Waldhoer, Thomas

AU - Jarosz-Chobot, Przemyslawa

AU - Gimeno, Suely G A

AU - Chuang, Lee-Ming

AU - Parslow, Roger C

AU - Wadsworth, Emma J K

AU - Chetwynd, Amanda

AU - Pozzilli, Paolo

AU - Brigis, Girts

AU - Urbonaite, Brone

AU - Sipetic, Sandra

AU - Schober, Edith

AU - Devoti, Gabriele

AU - Ionescu-Tirgoviste, Constantin

AU - de Beaufort, Carine E

AU - Stoyanov, Denka

AU - Buschard, Karsten

AU - Patterson, Chris C

N1 - Keywords: Adolescent; Adult; Age of Onset; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Diabetes Mellitus, Type 1; Female; Humans; Maternal Age; Meta-Analysis as Topic; Odds Ratio; Regression Analysis; Reproducibility of Results

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS: Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS: Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I(2) = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS: There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.

AB - OBJECTIVE: The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS: Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS: Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I(2) = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS: There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.

U2 - 10.2337/db09-1166

DO - 10.2337/db09-1166

M3 - Journal article

C2 - 19875616

VL - 59

SP - 486

EP - 494

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 2

ER -

ID: 18698977