Looking Back on 50 Years of Literature to Understand the Potential Impact of Influenza on Extrapulmonary Medical Outcomes
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Looking Back on 50 Years of Literature to Understand the Potential Impact of Influenza on Extrapulmonary Medical Outcomes. / Nealon, Joshua; Derqui, Nieves; De Courville, Caroline; Biering-Sørensen, Tor; Cowling, Benjamin J.; Nair, Harish; Chaves, Sandra S.
In: Open Forum Infectious Diseases, Vol. 9, No. 8, ofac352, 2022, p. 1-8.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Looking Back on 50 Years of Literature to Understand the Potential Impact of Influenza on Extrapulmonary Medical Outcomes
AU - Nealon, Joshua
AU - Derqui, Nieves
AU - De Courville, Caroline
AU - Biering-Sørensen, Tor
AU - Cowling, Benjamin J.
AU - Nair, Harish
AU - Chaves, Sandra S.
N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2022
Y1 - 2022
N2 - We conducted a scoping review of the epidemiological literature from the past 50 years to document the contribution of influenza virus infection to extrapulmonary clinical outcomes. We identified 99 publications reporting 243 associations using many study designs, exposure and outcome definitions, and methods. Laboratory confirmation of influenza was used in only 28 (12%) estimates, mostly in case-control and self-controlled case series study designs. We identified 50 individual clinical conditions associated with influenza. The most numerous estimates were of cardiocirculatory diseases, neurological/neuromuscular diseases, and fetal/newborn disorders, with myocardial infarction the most common individual outcome. Due to heterogeneity, we could not generate summary estimates of effect size, but of 130 relative effect estimates, 105 (81%) indicated an elevated risk of extrapulmonary outcome with influenza exposure. The literature is indicative of systemic complications of influenza virus infection, the requirement for more effective influenza control, and a need for robust confirmatory studies.
AB - We conducted a scoping review of the epidemiological literature from the past 50 years to document the contribution of influenza virus infection to extrapulmonary clinical outcomes. We identified 99 publications reporting 243 associations using many study designs, exposure and outcome definitions, and methods. Laboratory confirmation of influenza was used in only 28 (12%) estimates, mostly in case-control and self-controlled case series study designs. We identified 50 individual clinical conditions associated with influenza. The most numerous estimates were of cardiocirculatory diseases, neurological/neuromuscular diseases, and fetal/newborn disorders, with myocardial infarction the most common individual outcome. Due to heterogeneity, we could not generate summary estimates of effect size, but of 130 relative effect estimates, 105 (81%) indicated an elevated risk of extrapulmonary outcome with influenza exposure. The literature is indicative of systemic complications of influenza virus infection, the requirement for more effective influenza control, and a need for robust confirmatory studies.
KW - cardiovascular
KW - epidemiology
KW - extrapulmonary
KW - influenza
KW - review
UR - http://www.scopus.com/inward/record.url?scp=85135705072&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofac352
DO - 10.1093/ofid/ofac352
M3 - Review
C2 - 35937650
AN - SCOPUS:85135705072
VL - 9
SP - 1
EP - 8
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 8
M1 - ofac352
ER -
ID: 317098715