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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. / Ullitz Thorsen, Steffen; Liu, Xiang; Kataria, Yachana; Mandrup-poulsen, Thomas; Kaur, Simranjeet; Uusitalo, Ulla; Virtanen, Suvi M.; Norris, Jill; Rewers, Marian; Hagopian, William; Yang, Jimin; She, Jin-xiong; Akolkar, Beena; Rich, Stephen S.; Aronsson, Carin Andrén; Lernmark, Åke; Ziegler, Anette-gabriele; Toppari, Jorma; Krischer, Jeffrey P.; Parikh, Hemang M.; Ellervik, Christina; Svensson, Jannet; Rewers, Marian; Barbour, Aaron; Bautista, Kimberly; Baxter, Judith; Felipe-morales, Daniel; Frohnert, Brigitte I.; Stahl, Marisa; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Liu, Edwin; Munoz, Alondra; Norris, Jill; O’donnell, Holly; Peacock, Stesha; Shorrosh, Hanan; Steck, Andrea; Stern, Megan; Waugh, Kathleen; Toppari, Jorma; Simell, Olli G.; Adamsson, Annika; Ahonen, Suvi; Åkerlund, Mari; Anttila, Sirpa; Hakola, Leena; Hekkala, Anne; Agardh, Daniel; Environmental Determinants of Diabetes in the Young (TEDDY) Group.
In:
Diabetes Care, Vol. 46, No. 5, 2023, p. 1-5.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Ullitz Thorsen, S, Liu, X, Kataria, Y
, Mandrup-poulsen, T, Kaur, S, Uusitalo, U, Virtanen, SM, Norris, J, Rewers, M, Hagopian, W, Yang, J, She, J, Akolkar, B, Rich, SS, Aronsson, CA, Lernmark, Å, Ziegler, A, Toppari, J, Krischer, JP, Parikh, HM
, Ellervik, C, Svensson, J, Rewers, M, Barbour, A, Bautista, K, Baxter, J, Felipe-morales, D, Frohnert, BI, Stahl, M, Gesualdo, P, Hoffman, M, Karban, R, Liu, E, Munoz, A, Norris, J, O’donnell, H, Peacock, S, Shorrosh, H, Steck, A, Stern, M, Waugh, K, Toppari, J, Simell, OG, Adamsson, A, Ahonen, S, Åkerlund, M, Anttila, S, Hakola, L, Hekkala, A, Agardh, D & Environmental Determinants of Diabetes in the Young (TEDDY) Group 2023, '
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study',
Diabetes Care, vol. 46, no. 5, pp. 1-5.
https://doi.org/10.2337/dc22-1359APA
Ullitz Thorsen, S., Liu, X., Kataria, Y.
, Mandrup-poulsen, T., Kaur, S., Uusitalo, U., Virtanen, S. M., Norris, J., Rewers, M., Hagopian, W., Yang, J., She, J., Akolkar, B., Rich, S. S., Aronsson, C. A., Lernmark, Å., Ziegler, A., Toppari, J., Krischer, J. P., ... Environmental Determinants of Diabetes in the Young (TEDDY) Group (2023).
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study.
Diabetes Care,
46(5), 1-5.
https://doi.org/10.2337/dc22-1359Vancouver
Ullitz Thorsen S, Liu X, Kataria Y
, Mandrup-poulsen T, Kaur S, Uusitalo U et al.
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study.
Diabetes Care. 2023;46(5):1-5.
https://doi.org/10.2337/dc22-1359Author
Ullitz Thorsen, Steffen ; Liu, Xiang ; Kataria, Yachana ; Mandrup-poulsen, Thomas ; Kaur, Simranjeet ; Uusitalo, Ulla ; Virtanen, Suvi M. ; Norris, Jill ; Rewers, Marian ; Hagopian, William ; Yang, Jimin ; She, Jin-xiong ; Akolkar, Beena ; Rich, Stephen S. ; Aronsson, Carin Andrén ; Lernmark, Åke ; Ziegler, Anette-gabriele ; Toppari, Jorma ; Krischer, Jeffrey P. ; Parikh, Hemang M. ; Ellervik, Christina ; Svensson, Jannet ; Rewers, Marian ; Barbour, Aaron ; Bautista, Kimberly ; Baxter, Judith ; Felipe-morales, Daniel ; Frohnert, Brigitte I. ; Stahl, Marisa ; Gesualdo, Patricia ; Hoffman, Michelle ; Karban, Rachel ; Liu, Edwin ; Munoz, Alondra ; Norris, Jill ; O’donnell, Holly ; Peacock, Stesha ; Shorrosh, Hanan ; Steck, Andrea ; Stern, Megan ; Waugh, Kathleen ; Toppari, Jorma ; Simell, Olli G. ; Adamsson, Annika ; Ahonen, Suvi ; Åkerlund, Mari ; Anttila, Sirpa ; Hakola, Leena ; Hekkala, Anne ; Agardh, Daniel ; Environmental Determinants of Diabetes in the Young (TEDDY) Group. / Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. In: Diabetes Care. 2023 ; Vol. 46, No. 5. pp. 1-5.
Bibtex
@article{8f212276664442518800850659b936c9,
title = "Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study",
abstract = "OBJECTIVETo examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.",
author = "{Ullitz Thorsen}, Steffen and Xiang Liu and Yachana Kataria and Thomas Mandrup-poulsen and Simranjeet Kaur and Ulla Uusitalo and Virtanen, {Suvi M.} and Jill Norris and Marian Rewers and William Hagopian and Jimin Yang and Jin-xiong She and Beena Akolkar and Rich, {Stephen S.} and Aronsson, {Carin Andr{\'e}n} and {\AA}ke Lernmark and Anette-gabriele Ziegler and Jorma Toppari and Krischer, {Jeffrey P.} and Parikh, {Hemang M.} and Christina Ellervik and Jannet Svensson and Marian Rewers and Aaron Barbour and Kimberly Bautista and Judith Baxter and Daniel Felipe-morales and Frohnert, {Brigitte I.} and Marisa Stahl and Patricia Gesualdo and Michelle Hoffman and Rachel Karban and Edwin Liu and Alondra Munoz and Jill Norris and Holly O{\textquoteright}donnell and Stesha Peacock and Hanan Shorrosh and Andrea Steck and Megan Stern and Kathleen Waugh and Jorma Toppari and Simell, {Olli G.} and Annika Adamsson and Suvi Ahonen and Mari {\AA}kerlund and Sirpa Anttila and Leena Hakola and Anne Hekkala and Daniel Agardh and {Environmental Determinants of Diabetes in the Young (TEDDY) Group}",
year = "2023",
doi = "10.2337/dc22-1359",
language = "English",
volume = "46",
pages = "1--5",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association",
number = "5",
}
RIS
TY - JOUR
T1 - Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload
T2 - Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
AU - Ullitz Thorsen, Steffen
AU - Liu, Xiang
AU - Kataria, Yachana
AU - Mandrup-poulsen, Thomas
AU - Kaur, Simranjeet
AU - Uusitalo, Ulla
AU - Virtanen, Suvi M.
AU - Norris, Jill
AU - Rewers, Marian
AU - Hagopian, William
AU - Yang, Jimin
AU - She, Jin-xiong
AU - Akolkar, Beena
AU - Rich, Stephen S.
AU - Aronsson, Carin Andrén
AU - Lernmark, Åke
AU - Ziegler, Anette-gabriele
AU - Toppari, Jorma
AU - Krischer, Jeffrey P.
AU - Parikh, Hemang M.
AU - Ellervik, Christina
AU - Svensson, Jannet
AU - Rewers, Marian
AU - Barbour, Aaron
AU - Bautista, Kimberly
AU - Baxter, Judith
AU - Felipe-morales, Daniel
AU - Frohnert, Brigitte I.
AU - Stahl, Marisa
AU - Gesualdo, Patricia
AU - Hoffman, Michelle
AU - Karban, Rachel
AU - Liu, Edwin
AU - Munoz, Alondra
AU - Norris, Jill
AU - O’donnell, Holly
AU - Peacock, Stesha
AU - Shorrosh, Hanan
AU - Steck, Andrea
AU - Stern, Megan
AU - Waugh, Kathleen
AU - Toppari, Jorma
AU - Simell, Olli G.
AU - Adamsson, Annika
AU - Ahonen, Suvi
AU - Åkerlund, Mari
AU - Anttila, Sirpa
AU - Hakola, Leena
AU - Hekkala, Anne
AU - Agardh, Daniel
AU - Environmental Determinants of Diabetes in the Young (TEDDY) Group
PY - 2023
Y1 - 2023
N2 - OBJECTIVETo examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
AB - OBJECTIVETo examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
U2 - 10.2337/dc22-1359
DO - 10.2337/dc22-1359
M3 - Journal article
C2 - 36867433
VL - 46
SP - 1
EP - 5
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 5
ER -
