Increased body mass index predicts severity of asthma symptoms but not objective asthma traits in a large sample of asthmatics
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Increased body mass index predicts severity of asthma symptoms but not objective asthma traits in a large sample of asthmatics. / Bildstrup, Line; Backer, Vibeke; Thomsen, Simon Francis.
In: Journal of Asthma, Vol. 52, No. 7, 09.2015, p. 687-92.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased body mass index predicts severity of asthma symptoms but not objective asthma traits in a large sample of asthmatics
AU - Bildstrup, Line
AU - Backer, Vibeke
AU - Thomsen, Simon Francis
PY - 2015/9
Y1 - 2015/9
N2 - AIM: To examine the relationship between body mass index (BMI) and different indicators of asthma severity in a large community-based sample of Danish adolescents and adults.METHODS: A total of 1186 subjects, 14-44 years of age, who in a screening questionnaire had reported a history of airway symptoms suggestive of asthma and/or allergy, or who were taking any medication for these conditions were clinically examined. All participants were interviewed about respiratory symptoms and furthermore height and weight, skin test reactivity, lung function, and airway responsiveness were measured.RESULTS: A total of 516 individuals had asthma. The mean BMI was 24.9 kg/m(2) (SD = 5.1). Asthma severity measured by GINA score increased with increasing BMI (p = 0.009). The result remained significant after adjusting for age, sex, medication use for asthma and smoking (p = 0.010). Severity of individual asthma symptoms; cough (p = 0.002) and chest tightness (p = 0.023) was also significantly related to BMI, whereas severity of wheezing and shortness of breath was not. Airway obstruction was more pronounced in subjects with increased BMI (p < 0.001) but the effect disappeared after adjustment for covariates (p = 0.233). Lung function, airway responsiveness, and atopy were not significantly related to BMI as were use of medication for asthma and adherence to treatment.CONCLUSIONS: In adults, increased body mass index predicts severity of asthma symptoms but not objective asthma traits.
AB - AIM: To examine the relationship between body mass index (BMI) and different indicators of asthma severity in a large community-based sample of Danish adolescents and adults.METHODS: A total of 1186 subjects, 14-44 years of age, who in a screening questionnaire had reported a history of airway symptoms suggestive of asthma and/or allergy, or who were taking any medication for these conditions were clinically examined. All participants were interviewed about respiratory symptoms and furthermore height and weight, skin test reactivity, lung function, and airway responsiveness were measured.RESULTS: A total of 516 individuals had asthma. The mean BMI was 24.9 kg/m(2) (SD = 5.1). Asthma severity measured by GINA score increased with increasing BMI (p = 0.009). The result remained significant after adjusting for age, sex, medication use for asthma and smoking (p = 0.010). Severity of individual asthma symptoms; cough (p = 0.002) and chest tightness (p = 0.023) was also significantly related to BMI, whereas severity of wheezing and shortness of breath was not. Airway obstruction was more pronounced in subjects with increased BMI (p < 0.001) but the effect disappeared after adjustment for covariates (p = 0.233). Lung function, airway responsiveness, and atopy were not significantly related to BMI as were use of medication for asthma and adherence to treatment.CONCLUSIONS: In adults, increased body mass index predicts severity of asthma symptoms but not objective asthma traits.
KW - Adolescent
KW - Adult
KW - Asthma
KW - Body Mass Index
KW - Cough
KW - Denmark
KW - Dyspnea
KW - Female
KW - Humans
KW - Male
KW - Respiratory Function Tests
KW - Respiratory Sounds
KW - Risk Factors
KW - Severity of Illness Index
KW - Young Adult
U2 - 10.3109/02770903.2015.1005840
DO - 10.3109/02770903.2015.1005840
M3 - Journal article
C2 - 25582044
VL - 52
SP - 687
EP - 692
JO - Journal of Asthma
JF - Journal of Asthma
SN - 0277-0903
IS - 7
ER -
ID: 161187034