In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. / Perentes, Jean Y; McKee, Trevor D; Ley, Carsten D; Mathiew, Hannah; Dawson, Michelle; Padera, Timothy P; Munn, Lance L; Jain, Rakesh K; Boucher, Yves.

In: Nature Methods, Vol. 6, No. 2, 2009, p. 143-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Perentes, JY, McKee, TD, Ley, CD, Mathiew, H, Dawson, M, Padera, TP, Munn, LL, Jain, RK & Boucher, Y 2009, 'In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts', Nature Methods, vol. 6, no. 2, pp. 143-5. https://doi.org/10.1038/nmeth.1295

APA

Perentes, J. Y., McKee, T. D., Ley, C. D., Mathiew, H., Dawson, M., Padera, T. P., Munn, L. L., Jain, R. K., & Boucher, Y. (2009). In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nature Methods, 6(2), 143-5. https://doi.org/10.1038/nmeth.1295

Vancouver

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP et al. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nature Methods. 2009;6(2):143-5. https://doi.org/10.1038/nmeth.1295

Author

Perentes, Jean Y ; McKee, Trevor D ; Ley, Carsten D ; Mathiew, Hannah ; Dawson, Michelle ; Padera, Timothy P ; Munn, Lance L ; Jain, Rakesh K ; Boucher, Yves. / In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. In: Nature Methods. 2009 ; Vol. 6, No. 2. pp. 143-5.

Bibtex

@article{9803eaf0359f11df8ed1000ea68e967b,
title = "In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts",
abstract = "Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.",
author = "Perentes, {Jean Y} and McKee, {Trevor D} and Ley, {Carsten D} and Hannah Mathiew and Michelle Dawson and Padera, {Timothy P} and Munn, {Lance L} and Jain, {Rakesh K} and Yves Boucher",
note = "Keywords: Animals; Cell Line, Tumor; Cell Movement; Collagen; Extracellular Matrix; Fibroblasts; Humans; Image Enhancement; Integrin beta Chains; Mice; Mice, Transgenic; Microscopy, Confocal; Relaxin; Soft Tissue Neoplasms; Stromal Cells",
year = "2009",
doi = "10.1038/nmeth.1295",
language = "English",
volume = "6",
pages = "143--5",
journal = "Nature Methods",
issn = "1548-7091",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

AU - Perentes, Jean Y

AU - McKee, Trevor D

AU - Ley, Carsten D

AU - Mathiew, Hannah

AU - Dawson, Michelle

AU - Padera, Timothy P

AU - Munn, Lance L

AU - Jain, Rakesh K

AU - Boucher, Yves

N1 - Keywords: Animals; Cell Line, Tumor; Cell Movement; Collagen; Extracellular Matrix; Fibroblasts; Humans; Image Enhancement; Integrin beta Chains; Mice; Mice, Transgenic; Microscopy, Confocal; Relaxin; Soft Tissue Neoplasms; Stromal Cells

PY - 2009

Y1 - 2009

N2 - Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.

AB - Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.

U2 - 10.1038/nmeth.1295

DO - 10.1038/nmeth.1295

M3 - Journal article

C2 - 19151720

VL - 6

SP - 143

EP - 145

JO - Nature Methods

JF - Nature Methods

SN - 1548-7091

IS - 2

ER -

ID: 18764243