In vitro evaluation of a new nitrosourea, TCNU, against human small cell lung cancer cell lines

Research output: Contribution to journal › Journal article › Research › peer-review

  • H Roed
  • L L Vindeløv
  • M Spang-Thomsen
  • I J Christensen
  • H H Hansen
The cytotoxic activity of a new nitrosourea, TCNU, was compared with that of BCNU in five human small cell lung cancer cell lines in vitro. TCNU was found to be equivalent or inferior to BCNU when compared on a microgram to microgram basis. If the potential of in vitro phase II trials for selection of new drugs can be validated, it can be concluded that TCNU is not superior to other nitrosoureas for the treatment of SCCL.
Original languageEnglish
JournalCancer Chemotherapy and Pharmacology
Volume19
Issue number4
Pages (from-to)315-8
Number of pages3
ISSN0344-5704
Publication statusPublished - 1987

Bibliographical note

Keywords: Carcinoma, Small Cell; Carmustine; Cell Cycle; Cell Line; Colony-Forming Units Assay; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Lung Neoplasms; Nitrosourea Compounds; Taurine; Tumor Stem Cell Assay

ID: 12871075