Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery

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Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery. / Chen, Zhi-Wu; Yang, Qin; Huang, Yu; Fan, Li; Li, Xian-Wu; He, Guo-Wei.

In: Vascular Pharmacology, Vol. 52, No. 1-2, 2009, p. 70-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chen, Z-W, Yang, Q, Huang, Y, Fan, L, Li, X-W & He, G-W 2009, 'Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery', Vascular Pharmacology, vol. 52, no. 1-2, pp. 70-6. https://doi.org/10.1016/j.vph.2009.11.003

APA

Chen, Z-W., Yang, Q., Huang, Y., Fan, L., Li, X-W., & He, G-W. (2009). Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery. Vascular Pharmacology, 52(1-2), 70-6. https://doi.org/10.1016/j.vph.2009.11.003

Vancouver

Chen Z-W, Yang Q, Huang Y, Fan L, Li X-W, He G-W. Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery. Vascular Pharmacology. 2009;52(1-2):70-6. https://doi.org/10.1016/j.vph.2009.11.003

Author

Chen, Zhi-Wu ; Yang, Qin ; Huang, Yu ; Fan, Li ; Li, Xian-Wu ; He, Guo-Wei. / Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery. In: Vascular Pharmacology. 2009 ; Vol. 52, No. 1-2. pp. 70-6.

Bibtex

@article{1715851035a011df8ed1000ea68e967b,
title = "Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery",
abstract = "AIMS: Internal mammary (IMA) and radial artery (RA) have different incidence of vasospasm and long-term patency rates in arterial grafting. We compared the vasoreactivity of human urotensin II (hU-II) and its receptor with mechanism investigations in IMA and RA. METHODS: IMA and RA taken from patients undergoing coronary bypass surgery were studied in organ baths. Urotensin receptor expression was determined by RT-PCR. RESULTS: hU-II contracted IMA with pD(2) of 8.57+/-0.41 and 45.4+/-9.1% E(max) of contraction to 100 mM KCl, whereas caused less contractile responses in RA (pD(2):8.30+/-0.79, E(max):20.4+/-4.8%, p<0.05). Nifedipine inhibited hU-II-contraction in IMA. In U(46619)-precontraction, hU-II elicited comparable relaxation in IMA (pD(2):8.39+/-0.43, E(max):56.1+/-4.0%) and RA (pD(2):9.03+/-0.46, E(max):65.2+/-7.1%). The relaxation was abolished by endothelium denudation and by indomethacin, oxadiazoloquinoxalinone or N(omega)-nitro-L-arginine, oxyhemoglobin, and Ca2+-activated K+ channel (K(Ca)) blockers. Urotensin receptor mRNA was detected in both arteries. CONCLUSIONS: hU-II is an important spasmogen in arterial grafts with receptors expressed in IMA and RA. hU-II elicits stronger contraction in IMA than in RA and a moderate endothelium-dependent relaxation attributable to nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor with involvement of K(Ca) activation. The relaxant response of endothelium-intact IMA and RA to hU-II demonstrates the importance of preservation of endothelium in these grafts.",
author = "Zhi-Wu Chen and Qin Yang and Yu Huang and Li Fan and Xian-Wu Li and Guo-Wei He",
note = "2009 Elsevier Inc. All rights reserved.",
year = "2009",
doi = "10.1016/j.vph.2009.11.003",
language = "English",
volume = "52",
pages = "70--6",
journal = "Vascular Pharmacology",
issn = "1537-1891",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery

AU - Chen, Zhi-Wu

AU - Yang, Qin

AU - Huang, Yu

AU - Fan, Li

AU - Li, Xian-Wu

AU - He, Guo-Wei

N1 - 2009 Elsevier Inc. All rights reserved.

PY - 2009

Y1 - 2009

N2 - AIMS: Internal mammary (IMA) and radial artery (RA) have different incidence of vasospasm and long-term patency rates in arterial grafting. We compared the vasoreactivity of human urotensin II (hU-II) and its receptor with mechanism investigations in IMA and RA. METHODS: IMA and RA taken from patients undergoing coronary bypass surgery were studied in organ baths. Urotensin receptor expression was determined by RT-PCR. RESULTS: hU-II contracted IMA with pD(2) of 8.57+/-0.41 and 45.4+/-9.1% E(max) of contraction to 100 mM KCl, whereas caused less contractile responses in RA (pD(2):8.30+/-0.79, E(max):20.4+/-4.8%, p<0.05). Nifedipine inhibited hU-II-contraction in IMA. In U(46619)-precontraction, hU-II elicited comparable relaxation in IMA (pD(2):8.39+/-0.43, E(max):56.1+/-4.0%) and RA (pD(2):9.03+/-0.46, E(max):65.2+/-7.1%). The relaxation was abolished by endothelium denudation and by indomethacin, oxadiazoloquinoxalinone or N(omega)-nitro-L-arginine, oxyhemoglobin, and Ca2+-activated K+ channel (K(Ca)) blockers. Urotensin receptor mRNA was detected in both arteries. CONCLUSIONS: hU-II is an important spasmogen in arterial grafts with receptors expressed in IMA and RA. hU-II elicits stronger contraction in IMA than in RA and a moderate endothelium-dependent relaxation attributable to nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor with involvement of K(Ca) activation. The relaxant response of endothelium-intact IMA and RA to hU-II demonstrates the importance of preservation of endothelium in these grafts.

AB - AIMS: Internal mammary (IMA) and radial artery (RA) have different incidence of vasospasm and long-term patency rates in arterial grafting. We compared the vasoreactivity of human urotensin II (hU-II) and its receptor with mechanism investigations in IMA and RA. METHODS: IMA and RA taken from patients undergoing coronary bypass surgery were studied in organ baths. Urotensin receptor expression was determined by RT-PCR. RESULTS: hU-II contracted IMA with pD(2) of 8.57+/-0.41 and 45.4+/-9.1% E(max) of contraction to 100 mM KCl, whereas caused less contractile responses in RA (pD(2):8.30+/-0.79, E(max):20.4+/-4.8%, p<0.05). Nifedipine inhibited hU-II-contraction in IMA. In U(46619)-precontraction, hU-II elicited comparable relaxation in IMA (pD(2):8.39+/-0.43, E(max):56.1+/-4.0%) and RA (pD(2):9.03+/-0.46, E(max):65.2+/-7.1%). The relaxation was abolished by endothelium denudation and by indomethacin, oxadiazoloquinoxalinone or N(omega)-nitro-L-arginine, oxyhemoglobin, and Ca2+-activated K+ channel (K(Ca)) blockers. Urotensin receptor mRNA was detected in both arteries. CONCLUSIONS: hU-II is an important spasmogen in arterial grafts with receptors expressed in IMA and RA. hU-II elicits stronger contraction in IMA than in RA and a moderate endothelium-dependent relaxation attributable to nitric oxide, prostacyclin, and endothelium-derived hyperpolarizing factor with involvement of K(Ca) activation. The relaxant response of endothelium-intact IMA and RA to hU-II demonstrates the importance of preservation of endothelium in these grafts.

U2 - 10.1016/j.vph.2009.11.003

DO - 10.1016/j.vph.2009.11.003

M3 - Journal article

C2 - 19962453

VL - 52

SP - 70

EP - 76

JO - Vascular Pharmacology

JF - Vascular Pharmacology

SN - 1537-1891

IS - 1-2

ER -

ID: 18764346