Growth kinetics of four human breast carcinomas grown in nude mice
Research output: Contribution to journal › Journal article › Research › peer-review
The immune-deficient nude mouse with human tumor xenografts is an appropriate model system for performing detailed growth kinetic examinations. In the present study one estrogen and progesterone receptor-negative (T60) and three receptor-positive (Br-10, MCF-7, T61) human breast cancer xenografts in nude mice were investigated. The proliferative tumor characteristics were examined by growth curves, thymidine labelling technique, and flow cytometric DNA analysis performed on fine-needle aspirations. The results showed that the tumors had growth kinetics comparable to other human tumor types with cell generation times of 42 to 60 hours. The three receptor-positive tumors had slower growth rate, larger tumor volume doubling time, and smaller growth fraction and labelling index than the receptor-negative tumor. However, no single proliferation parameter was sufficient to characterize the growth kinetics of individual tumors or to describe proliferative differences between the tumors.
Original language | English |
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Journal | Breast Cancer Research and Treatment |
Volume | 14 |
Issue number | 2 |
Pages (from-to) | 235-43 |
Number of pages | 8 |
ISSN | 0167-6806 |
Publication status | Published - 1989 |
Bibliographical note
Keywords: Animals; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Humans; Mice; Mice, Nude; Mitotic Index; Neoplasm Transplantation; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured
ID: 12870976