Growth differences between North American and European children at risk for type 1 diabetes
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Growth differences between North American and European children at risk for type 1 diabetes. / Nucci, Anita M; Becker, Dorothy J; Virtanen, Suvi M; Cuthbertson, David; Softness, Barney; Huot, Celine; Wasikowa, Renata; Dosch, Hans Michael; Akerblom, Hans K; Knip, Mikael; TRIGR Study Group ; Mandrup-Poulsen, Thomas.
In: Pediatric Diabetes Online, Vol. 13, No. 5, 08.2012, p. 425-31.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Growth differences between North American and European children at risk for type 1 diabetes
AU - Nucci, Anita M
AU - Becker, Dorothy J
AU - Virtanen, Suvi M
AU - Cuthbertson, David
AU - Softness, Barney
AU - Huot, Celine
AU - Wasikowa, Renata
AU - Dosch, Hans Michael
AU - Akerblom, Hans K
AU - Knip, Mikael
AU - TRIGR Study Group
AU - Mandrup-Poulsen, Thomas
N1 - © 2012 John Wiley & Sons A/S.
PY - 2012/8
Y1 - 2012/8
N2 - AIM: To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D.METHODS: Anthropometric indices between birth to 5 yr of age were compared among regions and T1D proband in 2160 children participating in the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk study.RESULTS: Children in Northern Europe had the highest weight z-score between birth to 12 months of age, while those in Southern Europe and U.S.A. had the lowest weight and length/height z-scores at most time points (p < 0.005 to p < 0.001). Few differences in z-score values for weight, height, and body mass index were found by maternal T1D status. Using International Obesity Task Force criteria, the obesity rates generally increased with age and at 5 yr were highest in males in Northern Europe (6.0%) and in females in Canada (12.8%). However, no statistically significance difference was found by geographic region. In Canada, the obesity rate for female children of mothers with and without T1D differed significantly at 4 and 5 yr (6.0 vs. 0.0% and 21.3 vs. 1.9%, respectively; p < 0.0125) but no differences by maternal T1D status were found in other regions.CONCLUSIONS: There are regional differences in early childhood growth that are consistent with the higher incidence of T1D in Northern Europe and Canada as compared to Southern Europe. Our prospective study from birth will allow evaluation of relationships between growth and the emerging development of autoimmunity and progression to T1D by region in this at-risk population of children.
AB - AIM: To evaluate the relationships between early growth and regional variations in type 1 diabetes (T1D) incidence in an international cohort of children with familial and genetic risk for T1D.METHODS: Anthropometric indices between birth to 5 yr of age were compared among regions and T1D proband in 2160 children participating in the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk study.RESULTS: Children in Northern Europe had the highest weight z-score between birth to 12 months of age, while those in Southern Europe and U.S.A. had the lowest weight and length/height z-scores at most time points (p < 0.005 to p < 0.001). Few differences in z-score values for weight, height, and body mass index were found by maternal T1D status. Using International Obesity Task Force criteria, the obesity rates generally increased with age and at 5 yr were highest in males in Northern Europe (6.0%) and in females in Canada (12.8%). However, no statistically significance difference was found by geographic region. In Canada, the obesity rate for female children of mothers with and without T1D differed significantly at 4 and 5 yr (6.0 vs. 0.0% and 21.3 vs. 1.9%, respectively; p < 0.0125) but no differences by maternal T1D status were found in other regions.CONCLUSIONS: There are regional differences in early childhood growth that are consistent with the higher incidence of T1D in Northern Europe and Canada as compared to Southern Europe. Our prospective study from birth will allow evaluation of relationships between growth and the emerging development of autoimmunity and progression to T1D by region in this at-risk population of children.
KW - Body Height
KW - Body Mass Index
KW - Body Weight
KW - Canada
KW - Child
KW - Child, Preschool
KW - Diabetes Mellitus, Type 1
KW - Europe
KW - European Continental Ancestry Group
KW - Female
KW - Growth
KW - Humans
KW - Infant
KW - Male
KW - Obesity
KW - Prospective Studies
KW - United States
U2 - 10.1111/j.1399-5448.2011.00840.x
DO - 10.1111/j.1399-5448.2011.00840.x
M3 - Journal article
C2 - 22251851
VL - 13
SP - 425
EP - 431
JO - Pediatric Diabetes
JF - Pediatric Diabetes
SN - 1399-543X
IS - 5
ER -
ID: 113810656