Giant glial cell: new insight through mechanism-based modeling
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Giant glial cell: new insight through mechanism-based modeling. / Postnov, D E; Ryazanova, L S; Brazhe, Nadezda; Brazhe, Alexey; Maximov, G V; Mosekilde, Erik; Sosnovtseva, Olga.
In: Journal of Biological Physics, Vol. 34, No. 3-4, 01.08.2008, p. 441-57.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Giant glial cell: new insight through mechanism-based modeling
AU - Postnov, D E
AU - Ryazanova, L S
AU - Brazhe, Nadezda
AU - Brazhe, Alexey
AU - Maximov, G V
AU - Mosekilde, Erik
AU - Sosnovtseva, Olga
PY - 2008/8/1
Y1 - 2008/8/1
N2 - The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.
AB - The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.
U2 - 10.1007/s10867-008-9070-7
DO - 10.1007/s10867-008-9070-7
M3 - Journal article
C2 - 19669488
VL - 34
SP - 441
EP - 457
JO - Journal of Biological Physics
JF - Journal of Biological Physics
SN - 0092-0606
IS - 3-4
ER -
ID: 33812338