Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort
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Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at
Original language | English |
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Article number | 68 |
Journal | Antioxidants |
Volume | 12 |
Issue number | 1 |
Number of pages | 13 |
ISSN | 2076-3921 |
DOIs | |
Publication status | Published - 2023 |
- gestational hypertension, HDL, cholesterol efflux capacity, paraoxonase-1, apolipoprotein M, pregnancy, obesity, APOLIPOPROTEIN-M, CARDIOVASCULAR-DISEASE, CHOLESTEROL EFFLUX, PREECLAMPSIA, PREGNANCY, PROTEIN, RISK, POLYMORPHISMS, CAPACITY
Research areas
ID: 335690724