Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives

Research output: Contribution to journal › Review › Research › peer-review

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Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives. / Gothelf, A.; Gehl, Julie.

In: Current Gene Therapy, Vol. 10, No. 4, 2010, p. 287-299.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Gothelf, A & Gehl, J 2010, 'Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives', Current Gene Therapy, vol. 10, no. 4, pp. 287-299.

APA

Gothelf, A., & Gehl, J. (2010). Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives. Current Gene Therapy, 10(4), 287-299.

Vancouver

Gothelf A, Gehl J. Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives. Current Gene Therapy. 2010;10(4):287-299.

Author

Gothelf, A. ; Gehl, Julie. / Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives. In: Current Gene Therapy. 2010 ; Vol. 10, No. 4. pp. 287-299.

Bibtex

@article{234438672ad64f06996e8ade2146299d,
title = "Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives",
abstract = "Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a non-viral means for transfecting genes into cells and tissues. It is a safe and efficient method and reports regarding the use of this technique in a variety of animal models and organs have been published in the literature. We find that gene electrotransfer to skin is of particular interest; not only due to the easy accessibility of this organ, which renders both treatment and evaluation feasible, but also the capability of the skin to produce transgenes and elicit immunological responses. Up to now more than 40 papers have been published in which gene electrotransfer was the technique used for gene transfection to skin in vivo. The aim of this review is to summarize which plasmids were injected and the electrical parameters applied. Furthermore an overview of the clinical perspectives of gene electrotransfer to skin will be presented",
author = "A. Gothelf and Julie Gehl",
year = "2010",
language = "English",
volume = "10",
pages = "287--299",
journal = "Current Gene Therapy",
issn = "1566-5232",
publisher = "Bentham Science Publishers",
number = "4",

}

RIS

TY - JOUR

T1 - Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives

AU - Gothelf, A.

AU - Gehl, Julie

PY - 2010

Y1 - 2010

N2 - Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a non-viral means for transfecting genes into cells and tissues. It is a safe and efficient method and reports regarding the use of this technique in a variety of animal models and organs have been published in the literature. We find that gene electrotransfer to skin is of particular interest; not only due to the easy accessibility of this organ, which renders both treatment and evaluation feasible, but also the capability of the skin to produce transgenes and elicit immunological responses. Up to now more than 40 papers have been published in which gene electrotransfer was the technique used for gene transfection to skin in vivo. The aim of this review is to summarize which plasmids were injected and the electrical parameters applied. Furthermore an overview of the clinical perspectives of gene electrotransfer to skin will be presented

AB - Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a non-viral means for transfecting genes into cells and tissues. It is a safe and efficient method and reports regarding the use of this technique in a variety of animal models and organs have been published in the literature. We find that gene electrotransfer to skin is of particular interest; not only due to the easy accessibility of this organ, which renders both treatment and evaluation feasible, but also the capability of the skin to produce transgenes and elicit immunological responses. Up to now more than 40 papers have been published in which gene electrotransfer was the technique used for gene transfection to skin in vivo. The aim of this review is to summarize which plasmids were injected and the electrical parameters applied. Furthermore an overview of the clinical perspectives of gene electrotransfer to skin will be presented

M3 - Review

VL - 10

SP - 287

EP - 299

JO - Current Gene Therapy

JF - Current Gene Therapy

SN - 1566-5232

IS - 4

ER -

ID: 34143385