Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain. / Tang, Jianbo; Postnov, Dmitry D.; Kilic, Kivilcim; Erdener, Sefik Evren; Lee, Blaire; Giblin, John T.; Szabo, Thomas L.; Boas, David A.

In: Advanced Science, Vol. 7, 2001044, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tang, J, Postnov, DD, Kilic, K, Erdener, SE, Lee, B, Giblin, JT, Szabo, TL & Boas, DA 2020, 'Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain', Advanced Science, vol. 7, 2001044. https://doi.org/10.1002/advs.202001044

APA

Tang, J., Postnov, D. D., Kilic, K., Erdener, S. E., Lee, B., Giblin, J. T., Szabo, T. L., & Boas, D. A. (2020). Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain. Advanced Science, 7, [2001044]. https://doi.org/10.1002/advs.202001044

Vancouver

Tang J, Postnov DD, Kilic K, Erdener SE, Lee B, Giblin JT et al. Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain. Advanced Science. 2020;7. 2001044. https://doi.org/10.1002/advs.202001044

Author

Tang, Jianbo ; Postnov, Dmitry D. ; Kilic, Kivilcim ; Erdener, Sefik Evren ; Lee, Blaire ; Giblin, John T. ; Szabo, Thomas L. ; Boas, David A. / Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain. In: Advanced Science. 2020 ; Vol. 7.

Bibtex

@article{5f43d9f2040f492d9b08348103cb6012,
title = "Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain",
abstract = "A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.",
keywords = "brain imaging, cerebral blood flow velocity, field autocorrelation function, functional ultrasound velocimetry",
author = "Jianbo Tang and Postnov, {Dmitry D.} and Kivilcim Kilic and Erdener, {Sefik Evren} and Blaire Lee and Giblin, {John T.} and Szabo, {Thomas L.} and Boas, {David A.}",
year = "2020",
doi = "10.1002/advs.202001044",
language = "English",
volume = "7",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley-VCH",

}

RIS

TY - JOUR

T1 - Functional Ultrasound Speckle Decorrelation-Based Velocimetry of the Brain

AU - Tang, Jianbo

AU - Postnov, Dmitry D.

AU - Kilic, Kivilcim

AU - Erdener, Sefik Evren

AU - Lee, Blaire

AU - Giblin, John T.

AU - Szabo, Thomas L.

AU - Boas, David A.

PY - 2020

Y1 - 2020

N2 - A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.

AB - A high-speed, contrast-free, quantitative ultrasound velocimetry (vUS) for blood flow velocity imaging throughout the rodent brain is developed based on the normalized first-order temporal autocorrelation function of the ultrasound field signal. vUS is able to quantify blood flow velocity in both transverse and axial directions, and is validated with numerical simulation, phantom experiments, and in vivo measurements. The functional imaging ability of vUS is demonstrated by monitoring the blood flow velocity changes during whisker stimulation in awake mice. Compared to existing Power-Doppler- and Color-Doppler-based functional ultrasound imaging techniques, vUS shows quantitative accuracy in estimating both axial and transverse flow speeds and resistance to acoustic attenuation and high-frequency noise.

KW - brain imaging

KW - cerebral blood flow velocity

KW - field autocorrelation function

KW - functional ultrasound velocimetry

U2 - 10.1002/advs.202001044

DO - 10.1002/advs.202001044

M3 - Journal article

C2 - 32999839

AN - SCOPUS:85088446374

VL - 7

JO - Advanced Science

JF - Advanced Science

SN - 2198-3844

M1 - 2001044

ER -

ID: 246825504