Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein
Research output: Contribution to journal › Journal article › Research › peer-review
New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.
Original language | English |
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Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 64 |
Issue number | 5 |
Pages (from-to) | 198-208 |
ISSN | 0362-4803 |
DOIs | |
Publication status | Published - 2021 |
ID: 256518381