Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development. / Benninger, Yves; Thurnherr, Tina; Pereira, Jorge A; Krause, Sven; Wu, Xunwei; Chrostek-Grashoff, Anna; Herzog, Dominik; Nave, Klaus-Armin; Franklin, Robin J M; Meijer, Dies; Brakebusch, Cord; Suter, Ueli; Relvas, João B.
In: Journal of Cell Biology, Vol. 177, No. 6, 2007, p. 1051-61.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
AU - Benninger, Yves
AU - Thurnherr, Tina
AU - Pereira, Jorge A
AU - Krause, Sven
AU - Wu, Xunwei
AU - Chrostek-Grashoff, Anna
AU - Herzog, Dominik
AU - Nave, Klaus-Armin
AU - Franklin, Robin J M
AU - Meijer, Dies
AU - Brakebusch, Cord
AU - Suter, Ueli
AU - Relvas, João B
N1 - Keywords: Animals; Axons; Cell Surface Extensions; Mice; Mice, Knockout; Neuropeptides; Peripheral Nervous System; Schwann Cells; cdc42 GTP-Binding Protein; rac GTP-Binding Proteins
PY - 2007
Y1 - 2007
N2 - During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.
AB - During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.
U2 - 10.1083/jcb.200610108
DO - 10.1083/jcb.200610108
M3 - Journal article
C2 - 17576798
VL - 177
SP - 1051
EP - 1061
JO - Journal of Cell Biology
JF - Journal of Cell Biology
SN - 0021-9525
IS - 6
ER -
ID: 5140818