Endocrine therapy of human breast cancer grown in nude mice

Research output: Contribution to journalJournal articleResearchpeer-review

  • N Brünner
  • C K Osborne
  • M Spang-Thomsen
Although there have been extensive studies of rodent breast tumor models, and of human breast cancer cell lines in culture, there is still need for a human tumor model which can be manipulated experimentally but also provides a valid expression of the tumor cells in a host environment. Athymic nude mice bearing transplanted human breast tumors have been proposed as such a model. This review therefore discusses the use of the athymic nude mouse model of the study of human breast cancer biology, and focuses on four subjects: 1. biological characteristics of heterotransplanted breast tumors; 2. endocrinology and pharmacology of hormonal agents in the nude mouse; 3. endocrine sensitivity of heterotransplanted tumors; and 4. applicability and limitations of this model for the study of human breast cancer.
Original languageEnglish
JournalBreast Cancer Research and Treatment
Volume10
Issue number3
Pages (from-to)229-42
Number of pages13
ISSN0167-6806
Publication statusPublished - 1987

Bibliographical note

Keywords: Animals; Breast Neoplasms; Disease Models, Animal; Female; Flow Cytometry; Hormones; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Transplantation, Heterologous

ID: 12871033