Endocrine therapy of human breast cancer grown in nude mice
Research output: Contribution to journal › Journal article › Research › peer-review
Although there have been extensive studies of rodent breast tumor models, and of human breast cancer cell lines in culture, there is still need for a human tumor model which can be manipulated experimentally but also provides a valid expression of the tumor cells in a host environment. Athymic nude mice bearing transplanted human breast tumors have been proposed as such a model. This review therefore discusses the use of the athymic nude mouse model of the study of human breast cancer biology, and focuses on four subjects: 1. biological characteristics of heterotransplanted breast tumors; 2. endocrinology and pharmacology of hormonal agents in the nude mouse; 3. endocrine sensitivity of heterotransplanted tumors; and 4. applicability and limitations of this model for the study of human breast cancer.
Original language | English |
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Journal | Breast Cancer Research and Treatment |
Volume | 10 |
Issue number | 3 |
Pages (from-to) | 229-42 |
Number of pages | 13 |
ISSN | 0167-6806 |
Publication status | Published - 1987 |
Bibliographical note
Keywords: Animals; Breast Neoplasms; Disease Models, Animal; Female; Flow Cytometry; Hormones; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Transplantation, Heterologous
ID: 12871033