Effects of aging on basal fat oxidation in obese humans
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Effects of aging on basal fat oxidation in obese humans. / Solomon, Thomas; Marchetti, Christine M; Krishnan, Raj K; Gonzalez, Frank; Kirwan, John P.
In: Metabolism: clinical and experimental, Vol. 57, No. 8, 08.2008, p. 1141-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of aging on basal fat oxidation in obese humans
AU - Solomon, Thomas
AU - Marchetti, Christine M
AU - Krishnan, Raj K
AU - Gonzalez, Frank
AU - Kirwan, John P
PY - 2008/8
Y1 - 2008/8
N2 - Basal fat oxidation decreases with age. In obesity, it is not known whether this age-related process occurs independently of changes in body composition and insulin sensitivity. Therefore, body composition, resting energy expenditure, basal substrate oxidation, and maximal oxygen consumption (VO(2)max) were measured in 10 older (age, 60 +/- 4 years; mean +/- SEM) and 10 younger (age, 35 +/- 4 years) body mass index-matched, obese, normal glucose-tolerant individuals. Fasting blood samples were also collected. Older subjects had slightly elevated fat mass (32.2 +/- 7.1 vs 36.5 +/- 6.7 kg, P = .16); however, waist circumference was not different between groups (104.3 +/- 10.3 vs 102.1 +/- 12.6 cm, P = .65). Basal fat oxidation was 22% lower (1.42 +/- 0.14 vs 1.17 +/- 0.22 mg/kg fat-free mass per minute, P = .03) in older subjects. The VO(2)max was also decreased in older individuals (44.6 +/- 7.1 vs 38.3 +/- 6.0 mL/kg fat-free mass per minute, P = .03); but insulin sensitivity, lipemia, and leptinemia were not different between groups (P > .05). Fat oxidation was most related to age (r = -0.61, P = .003) and VO(2)max (r = 0.52, P = .01). These data suggest that aging per se is responsible for reduced basal fat oxidation and maximal oxidative capacity in older obese individuals, independent of changes in insulin resistance, body mass, and abdominal fat. This indicates that age, in addition to obesity, is an independent risk factor for weight gain and for the metabolic complications of elevated body fat.
AB - Basal fat oxidation decreases with age. In obesity, it is not known whether this age-related process occurs independently of changes in body composition and insulin sensitivity. Therefore, body composition, resting energy expenditure, basal substrate oxidation, and maximal oxygen consumption (VO(2)max) were measured in 10 older (age, 60 +/- 4 years; mean +/- SEM) and 10 younger (age, 35 +/- 4 years) body mass index-matched, obese, normal glucose-tolerant individuals. Fasting blood samples were also collected. Older subjects had slightly elevated fat mass (32.2 +/- 7.1 vs 36.5 +/- 6.7 kg, P = .16); however, waist circumference was not different between groups (104.3 +/- 10.3 vs 102.1 +/- 12.6 cm, P = .65). Basal fat oxidation was 22% lower (1.42 +/- 0.14 vs 1.17 +/- 0.22 mg/kg fat-free mass per minute, P = .03) in older subjects. The VO(2)max was also decreased in older individuals (44.6 +/- 7.1 vs 38.3 +/- 6.0 mL/kg fat-free mass per minute, P = .03); but insulin sensitivity, lipemia, and leptinemia were not different between groups (P > .05). Fat oxidation was most related to age (r = -0.61, P = .003) and VO(2)max (r = 0.52, P = .01). These data suggest that aging per se is responsible for reduced basal fat oxidation and maximal oxidative capacity in older obese individuals, independent of changes in insulin resistance, body mass, and abdominal fat. This indicates that age, in addition to obesity, is an independent risk factor for weight gain and for the metabolic complications of elevated body fat.
KW - Adipose Tissue
KW - Adult
KW - Aging
KW - Anthropometry
KW - Basal Metabolism
KW - Blood Glucose
KW - Calorimetry, Indirect
KW - Cholesterol
KW - Female
KW - Humans
KW - Insulin
KW - Leptin
KW - Male
KW - Middle Aged
KW - Obesity
KW - Oxygen Consumption
KW - Triglycerides
U2 - 10.1016/j.metabol.2008.03.021
DO - 10.1016/j.metabol.2008.03.021
M3 - Journal article
C2 - 18640394
VL - 57
SP - 1141
EP - 1147
JO - Metabolism: clinical and experimental
JF - Metabolism: clinical and experimental
IS - 8
ER -
ID: 50218527