Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg. / Gabrielsen, Anders; Norsk, Peter.

In: Journal of Applied Physiology, Vol. 103, No. 3, 2007, p. 959-62.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gabrielsen, A & Norsk, P 2007, 'Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg.', Journal of Applied Physiology, vol. 103, no. 3, pp. 959-62. https://doi.org/10.1152/japplphysiol.00899.2006

APA

Gabrielsen, A., & Norsk, P. (2007). Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg. Journal of Applied Physiology, 103(3), 959-62. https://doi.org/10.1152/japplphysiol.00899.2006

Vancouver

Gabrielsen A, Norsk P. Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg. Journal of Applied Physiology. 2007;103(3):959-62. https://doi.org/10.1152/japplphysiol.00899.2006

Author

Gabrielsen, Anders ; Norsk, Peter. / Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg. In: Journal of Applied Physiology. 2007 ; Vol. 103, No. 3. pp. 959-62.

Bibtex

@article{45893930acd711ddb538000ea68e967b,
title = "Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg.",
abstract = "Whenever the legs are lowered in humans, a venoarteriolar reflex is activated by the hydrostatic distension of the venules. Through local axon reflexes, the adjacent arterioles are contracted to decrease blood flow and prevent formation of edema. Because the venoarteriolar reflex is activated by gravity, we tested the hypothesis that long-term weightlessness would attenuate it. The reduction in subcutaneous blood flow was measured by the (133)Xe washout technique just proximal to the ankle joint in dependent lower legs of eight supine astronauts, where the knee joint was passively bent by 90 degrees . The measurements were conducted before spaceflight and 3-6 h on landing following 4-6.5 mo in space. Activation of the venoarteriolar reflex reduced subcutaneous blood flow by 37 +/- 9% (P = 0.016) before flight and by 64 +/- 8% (P < 0.001) following landing with no statistical significant difference between the two reductions (P = 0.062). Therefore, our results show that the venoarteriolar reflex is not attenuated by weightlessness and therefore does not need the everyday stimulus of gravity to maintain efficiency.",
author = "Anders Gabrielsen and Peter Norsk",
note = "Keywords: Adult; Autonomic Pathways; Humans; Leg; Male; Middle Aged; Reflex; Regional Blood Flow; Space Flight; Vasoconstriction; Weightlessness",
year = "2007",
doi = "10.1152/japplphysiol.00899.2006",
language = "English",
volume = "103",
pages = "959--62",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of spaceflight on the subcutaneous venoarteriolar reflex in the human lower leg.

AU - Gabrielsen, Anders

AU - Norsk, Peter

N1 - Keywords: Adult; Autonomic Pathways; Humans; Leg; Male; Middle Aged; Reflex; Regional Blood Flow; Space Flight; Vasoconstriction; Weightlessness

PY - 2007

Y1 - 2007

N2 - Whenever the legs are lowered in humans, a venoarteriolar reflex is activated by the hydrostatic distension of the venules. Through local axon reflexes, the adjacent arterioles are contracted to decrease blood flow and prevent formation of edema. Because the venoarteriolar reflex is activated by gravity, we tested the hypothesis that long-term weightlessness would attenuate it. The reduction in subcutaneous blood flow was measured by the (133)Xe washout technique just proximal to the ankle joint in dependent lower legs of eight supine astronauts, where the knee joint was passively bent by 90 degrees . The measurements were conducted before spaceflight and 3-6 h on landing following 4-6.5 mo in space. Activation of the venoarteriolar reflex reduced subcutaneous blood flow by 37 +/- 9% (P = 0.016) before flight and by 64 +/- 8% (P < 0.001) following landing with no statistical significant difference between the two reductions (P = 0.062). Therefore, our results show that the venoarteriolar reflex is not attenuated by weightlessness and therefore does not need the everyday stimulus of gravity to maintain efficiency.

AB - Whenever the legs are lowered in humans, a venoarteriolar reflex is activated by the hydrostatic distension of the venules. Through local axon reflexes, the adjacent arterioles are contracted to decrease blood flow and prevent formation of edema. Because the venoarteriolar reflex is activated by gravity, we tested the hypothesis that long-term weightlessness would attenuate it. The reduction in subcutaneous blood flow was measured by the (133)Xe washout technique just proximal to the ankle joint in dependent lower legs of eight supine astronauts, where the knee joint was passively bent by 90 degrees . The measurements were conducted before spaceflight and 3-6 h on landing following 4-6.5 mo in space. Activation of the venoarteriolar reflex reduced subcutaneous blood flow by 37 +/- 9% (P = 0.016) before flight and by 64 +/- 8% (P < 0.001) following landing with no statistical significant difference between the two reductions (P = 0.062). Therefore, our results show that the venoarteriolar reflex is not attenuated by weightlessness and therefore does not need the everyday stimulus of gravity to maintain efficiency.

U2 - 10.1152/japplphysiol.00899.2006

DO - 10.1152/japplphysiol.00899.2006

M3 - Journal article

C2 - 17585042

VL - 103

SP - 959

EP - 962

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -

ID: 8466247