Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat. / Olsen, P S; Kirkegaard, P; Poulsen, Steen Seier; Nexø, Ebba.

In: Digestive Diseases and Sciences, Vol. 39, No. 10, 10.1994, p. 2186-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olsen, PS, Kirkegaard, P, Poulsen, SS & Nexø, E 1994, 'Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat', Digestive Diseases and Sciences, vol. 39, no. 10, pp. 2186-90.

APA

Olsen, P. S., Kirkegaard, P., Poulsen, S. S., & Nexø, E. (1994). Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat. Digestive Diseases and Sciences, 39(10), 2186-90.

Vancouver

Olsen PS, Kirkegaard P, Poulsen SS, Nexø E. Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat. Digestive Diseases and Sciences. 1994 Oct;39(10):2186-90.

Author

Olsen, P S ; Kirkegaard, P ; Poulsen, Steen Seier ; Nexø, Ebba. / Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat. In: Digestive Diseases and Sciences. 1994 ; Vol. 39, No. 10. pp. 2186-90.

Bibtex

@article{43fb019074ce11dbbee902004c4f4f50,
title = "Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat",
abstract = "The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmol/kg/hr of secretin. Somatostatin inhibited Brunner's gland secretion, but the total output of EGF remained unchanged. Secretin-stimulated volume secretion and secretion of EGF was significantly reduced by simultaneous infusion of somatostatin. This study has shown that secretin stimulates secretion of EGF as well as volume secretion from Brunner's glands. Somatostatin prevents the effect of secretin on Brunner's glands, which suggests a role for somatostatin in control of Brunner's gland secretion.",
keywords = "Animals, Brunner Glands, Dose-Response Relationship, Drug, Epidermal Growth Factor, Male, Radioimmunoassay, Rats, Rats, Wistar, Secretin, Secretory Rate, Somatostatin, Statistics, Nonparametric",
author = "Olsen, {P S} and P Kirkegaard and Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1994",
month = oct,
language = "English",
volume = "39",
pages = "2186--90",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Effect of secretin and somatostatin on secretion of epidermal growth factor from Brunner's glands in the rat

AU - Olsen, P S

AU - Kirkegaard, P

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1994/10

Y1 - 1994/10

N2 - The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmol/kg/hr of secretin. Somatostatin inhibited Brunner's gland secretion, but the total output of EGF remained unchanged. Secretin-stimulated volume secretion and secretion of EGF was significantly reduced by simultaneous infusion of somatostatin. This study has shown that secretin stimulates secretion of EGF as well as volume secretion from Brunner's glands. Somatostatin prevents the effect of secretin on Brunner's glands, which suggests a role for somatostatin in control of Brunner's gland secretion.

AB - The effect of secretin and somatostatin on secretion of epidermal growth factor (EGF) from Brunner's glands was investigated in rats. Secretin increased volume secretion and the median output of EGF rose from 720 fmol/5 hr (total range 460-1320) in controls to 2065 fmol/5 hr (total range 1560-2730) at a dose of 50 pmol/kg/hr of secretin. Somatostatin inhibited Brunner's gland secretion, but the total output of EGF remained unchanged. Secretin-stimulated volume secretion and secretion of EGF was significantly reduced by simultaneous infusion of somatostatin. This study has shown that secretin stimulates secretion of EGF as well as volume secretion from Brunner's glands. Somatostatin prevents the effect of secretin on Brunner's glands, which suggests a role for somatostatin in control of Brunner's gland secretion.

KW - Animals

KW - Brunner Glands

KW - Dose-Response Relationship, Drug

KW - Epidermal Growth Factor

KW - Male

KW - Radioimmunoassay

KW - Rats

KW - Rats, Wistar

KW - Secretin

KW - Secretory Rate

KW - Somatostatin

KW - Statistics, Nonparametric

M3 - Journal article

C2 - 7924740

VL - 39

SP - 2186

EP - 2190

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 10

ER -

ID: 259822