Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats

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Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats. / Poulsen, Steen Seier.

In: The Tohoku Journal of Experimental Medicine, Vol. 155, No. 4, 08.1988, p. 305-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS 1988, 'Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats', The Tohoku Journal of Experimental Medicine, vol. 155, no. 4, pp. 305-10.

APA

Poulsen, S. S. (1988). Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats. The Tohoku Journal of Experimental Medicine, 155(4), 305-10.

Vancouver

Poulsen SS. Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats. The Tohoku Journal of Experimental Medicine. 1988 Aug;155(4):305-10.

Author

Poulsen, Steen Seier. / Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats. In: The Tohoku Journal of Experimental Medicine. 1988 ; Vol. 155, No. 4. pp. 305-10.

Bibtex

@article{8a1daef2a9db4e548c10739f8dbc966b,
title = "Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats",
abstract = "The effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion was investigated in rats. The effect of three doses of omeprazole given orally once daily for 25 days was investigated. In controls median ulcer healing was 19.6% after 25 days. Omeprazole increased median ulcer healing from 36% at 145 mumole/kg/day to 80% at 580 mumole/kg/day. Basal and pentagastrin stimulated gastric acid secretion decreased dose-dependently by nearly 90% at a dose of 580 mumole/kg/day 22-24 hr after the last dose of omeprazole. Cimetidine given twice daily, in a dose that initially inhibits gastric acid secretion by 95%, reduced acid secretion by only 50% 11 hr after the last dose. Median ulcer healing after treatment with cimetidine for 25 days was 41%. This study demonstrates that omeprazole has a more long-acting inhibitory effect on gastric acid secretion compared to cimetidine and accelerates healing of chronic gastric ulcers dose-dependently in rats.",
keywords = "Animals, Cimetidine, Gastric Acid, Gastric Mucosa, Male, Omeprazole, Pentagastrin, Rats, Rats, Inbred Strains, Reference Values, Stomach Ulcer",
author = "Poulsen, {Steen Seier}",
year = "1988",
month = aug,
language = "English",
volume = "155",
pages = "305--10",
journal = "The Tohoku Journal of Experimental Medicine",
issn = "0040-8727",
publisher = "Tohoku University Medical Press",
number = "4",

}

RIS

TY - JOUR

T1 - Effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion in rats

AU - Poulsen, Steen Seier

PY - 1988/8

Y1 - 1988/8

N2 - The effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion was investigated in rats. The effect of three doses of omeprazole given orally once daily for 25 days was investigated. In controls median ulcer healing was 19.6% after 25 days. Omeprazole increased median ulcer healing from 36% at 145 mumole/kg/day to 80% at 580 mumole/kg/day. Basal and pentagastrin stimulated gastric acid secretion decreased dose-dependently by nearly 90% at a dose of 580 mumole/kg/day 22-24 hr after the last dose of omeprazole. Cimetidine given twice daily, in a dose that initially inhibits gastric acid secretion by 95%, reduced acid secretion by only 50% 11 hr after the last dose. Median ulcer healing after treatment with cimetidine for 25 days was 41%. This study demonstrates that omeprazole has a more long-acting inhibitory effect on gastric acid secretion compared to cimetidine and accelerates healing of chronic gastric ulcers dose-dependently in rats.

AB - The effect of omeprazole and cimetidine on healing of chronic gastric ulcers and gastric acid secretion was investigated in rats. The effect of three doses of omeprazole given orally once daily for 25 days was investigated. In controls median ulcer healing was 19.6% after 25 days. Omeprazole increased median ulcer healing from 36% at 145 mumole/kg/day to 80% at 580 mumole/kg/day. Basal and pentagastrin stimulated gastric acid secretion decreased dose-dependently by nearly 90% at a dose of 580 mumole/kg/day 22-24 hr after the last dose of omeprazole. Cimetidine given twice daily, in a dose that initially inhibits gastric acid secretion by 95%, reduced acid secretion by only 50% 11 hr after the last dose. Median ulcer healing after treatment with cimetidine for 25 days was 41%. This study demonstrates that omeprazole has a more long-acting inhibitory effect on gastric acid secretion compared to cimetidine and accelerates healing of chronic gastric ulcers dose-dependently in rats.

KW - Animals

KW - Cimetidine

KW - Gastric Acid

KW - Gastric Mucosa

KW - Male

KW - Omeprazole

KW - Pentagastrin

KW - Rats

KW - Rats, Inbred Strains

KW - Reference Values

KW - Stomach Ulcer

M3 - Journal article

C2 - 3232144

VL - 155

SP - 305

EP - 310

JO - The Tohoku Journal of Experimental Medicine

JF - The Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 4

ER -

ID: 47488363