EBF2 regulates osteoblast-dependent differentiation of osteoclasts.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

EBF2 regulates osteoblast-dependent differentiation of osteoclasts. / Kieslinger, Matthias; Folberth, Stephanie; Dobreva, Gergana; Dorn, Tatjana; Croci, Laura; Erben, Reinhold; Consalez, G Giacomo; Grosschedl, Rudolf.

In: Developmental Cell, Vol. 9, No. 6, 2005, p. 757-67.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kieslinger, M, Folberth, S, Dobreva, G, Dorn, T, Croci, L, Erben, R, Consalez, GG & Grosschedl, R 2005, 'EBF2 regulates osteoblast-dependent differentiation of osteoclasts.', Developmental Cell, vol. 9, no. 6, pp. 757-67. https://doi.org/10.1016/j.devcel.2005.10.009

APA

Kieslinger, M., Folberth, S., Dobreva, G., Dorn, T., Croci, L., Erben, R., Consalez, G. G., & Grosschedl, R. (2005). EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Developmental Cell, 9(6), 757-67. https://doi.org/10.1016/j.devcel.2005.10.009

Vancouver

Kieslinger M, Folberth S, Dobreva G, Dorn T, Croci L, Erben R et al. EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Developmental Cell. 2005;9(6):757-67. https://doi.org/10.1016/j.devcel.2005.10.009

Author

Kieslinger, Matthias ; Folberth, Stephanie ; Dobreva, Gergana ; Dorn, Tatjana ; Croci, Laura ; Erben, Reinhold ; Consalez, G Giacomo ; Grosschedl, Rudolf. / EBF2 regulates osteoblast-dependent differentiation of osteoclasts. In: Developmental Cell. 2005 ; Vol. 9, No. 6. pp. 757-67.

Bibtex

@article{214f0790acad11ddb5e9000ea68e967b,
title = "EBF2 regulates osteoblast-dependent differentiation of osteoclasts.",
abstract = "Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:beta-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.",
author = "Matthias Kieslinger and Stephanie Folberth and Gergana Dobreva and Tatjana Dorn and Laura Croci and Reinhold Erben and Consalez, {G Giacomo} and Rudolf Grosschedl",
note = "Keywords: Animals; Basic Helix-Loop-Helix Transcription Factors; Bone Development; Bone Resorption; Carrier Proteins; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Gene Expression Regulation; Glycoproteins; Hela Cells; Homozygote; Humans; In Situ Hybridization; Lymphoid Enhancer-Binding Factor 1; Membrane Glycoproteins; Mice; Mice, Knockout; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Promoter Regions (Genetics); RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Signal Transduction; T Cell Transcription Factor 1; Trans-Activation (Genetics); Trans-Activators; Wnt Proteins; beta Catenin",
year = "2005",
doi = "10.1016/j.devcel.2005.10.009",
language = "English",
volume = "9",
pages = "757--67",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - EBF2 regulates osteoblast-dependent differentiation of osteoclasts.

AU - Kieslinger, Matthias

AU - Folberth, Stephanie

AU - Dobreva, Gergana

AU - Dorn, Tatjana

AU - Croci, Laura

AU - Erben, Reinhold

AU - Consalez, G Giacomo

AU - Grosschedl, Rudolf

N1 - Keywords: Animals; Basic Helix-Loop-Helix Transcription Factors; Bone Development; Bone Resorption; Carrier Proteins; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Gene Expression Regulation; Glycoproteins; Hela Cells; Homozygote; Humans; In Situ Hybridization; Lymphoid Enhancer-Binding Factor 1; Membrane Glycoproteins; Mice; Mice, Knockout; Osteoblasts; Osteoclasts; Osteogenesis; Osteoprotegerin; Promoter Regions (Genetics); RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Signal Transduction; T Cell Transcription Factor 1; Trans-Activation (Genetics); Trans-Activators; Wnt Proteins; beta Catenin

PY - 2005

Y1 - 2005

N2 - Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:beta-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.

AB - Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:beta-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.

U2 - 10.1016/j.devcel.2005.10.009

DO - 10.1016/j.devcel.2005.10.009

M3 - Journal article

C2 - 16326388

VL - 9

SP - 757

EP - 767

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 6

ER -

ID: 8463192