Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors
Research output: Contribution to journal › Journal article › Research › peer-review
Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
| Original language | English |
|---|---|
| Journal | Journal of Medicinal Chemistry |
| Volume | 55 |
| Issue number | 18 |
| Pages (from-to) | 8178-82 |
| Number of pages | 5 |
| ISSN | 0022-2623 |
| DOIs | |
| Publication status | Published - 27 Sep 2012 |
- Animals, Antibodies, Monoclonal, Antigens, CD36, Biomimetic Materials, Chemistry Techniques, Synthetic, Drug Design, Drug Stability, Humans, Mice, Oxidation-Reduction, Phospholipid Ethers, Protein Binding, Solubility, Substrate Specificity, Water
Research areas
ID: 47720152