Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. / Turner, William W; Hartvigsen, Karsten; Boullier, Agnes; Montano, Erica N; Witztum, Joseph L; VanNieuwenhze, Michael S.

In: Journal of Medicinal Chemistry, Vol. 55, No. 18, 27.09.2012, p. 8178-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Turner, WW, Hartvigsen, K, Boullier, A, Montano, EN, Witztum, JL & VanNieuwenhze, MS 2012, 'Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors', Journal of Medicinal Chemistry, vol. 55, no. 18, pp. 8178-82. https://doi.org/10.1021/jm300685s

APA

Turner, W. W., Hartvigsen, K., Boullier, A., Montano, E. N., Witztum, J. L., & VanNieuwenhze, M. S. (2012). Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. Journal of Medicinal Chemistry, 55(18), 8178-82. https://doi.org/10.1021/jm300685s

Vancouver

Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum JL, VanNieuwenhze MS. Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. Journal of Medicinal Chemistry. 2012 Sep 27;55(18):8178-82. https://doi.org/10.1021/jm300685s

Author

Turner, William W ; Hartvigsen, Karsten ; Boullier, Agnes ; Montano, Erica N ; Witztum, Joseph L ; VanNieuwenhze, Michael S. / Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. In: Journal of Medicinal Chemistry. 2012 ; Vol. 55, No. 18. pp. 8178-82.

Bibtex

@article{1db8b804394c41fb934d2d921994de7b,
title = "Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors",
abstract = "Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.",
keywords = "Animals, Antibodies, Monoclonal, Antigens, CD36, Biomimetic Materials, Chemistry Techniques, Synthetic, Drug Design, Drug Stability, Humans, Mice, Oxidation-Reduction, Phospholipid Ethers, Protein Binding, Solubility, Substrate Specificity, Water",
author = "Turner, {William W} and Karsten Hartvigsen and Agnes Boullier and Montano, {Erica N} and Witztum, {Joseph L} and VanNieuwenhze, {Michael S}",
year = "2012",
month = sep,
day = "27",
doi = "10.1021/jm300685s",
language = "English",
volume = "55",
pages = "8178--82",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "18",

}

RIS

TY - JOUR

T1 - Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors

AU - Turner, William W

AU - Hartvigsen, Karsten

AU - Boullier, Agnes

AU - Montano, Erica N

AU - Witztum, Joseph L

AU - VanNieuwenhze, Michael S

PY - 2012/9/27

Y1 - 2012/9/27

N2 - Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.

AB - Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.

KW - Animals

KW - Antibodies, Monoclonal

KW - Antigens, CD36

KW - Biomimetic Materials

KW - Chemistry Techniques, Synthetic

KW - Drug Design

KW - Drug Stability

KW - Humans

KW - Mice

KW - Oxidation-Reduction

KW - Phospholipid Ethers

KW - Protein Binding

KW - Solubility

KW - Substrate Specificity

KW - Water

U2 - 10.1021/jm300685s

DO - 10.1021/jm300685s

M3 - Journal article

C2 - 22934615

VL - 55

SP - 8178

EP - 8182

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 18

ER -

ID: 47720152