Contact sensitization to fragrances in the general population: a Koch's approach may reveal the burden of disease
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Contact sensitization to fragrances in the general population: a Koch's approach may reveal the burden of disease. / Thyssen, J P; Menné, T; Linneberg, A; Johansen, J D.
In: British Journal of Dermatology, Vol. 160, No. 4, 2009, p. 729-35.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Contact sensitization to fragrances in the general population: a Koch's approach may reveal the burden of disease
AU - Thyssen, J P
AU - Menné, T
AU - Linneberg, A
AU - Johansen, J D
N1 - Keywords: Age Distribution; Dermatitis, Allergic Contact; Female; Humans; Male; Myroxylon; Patch Tests; Perfume; Plant Preparations; Prevalence; Questionnaires
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Contact sensitization to fragrance mix (FM) I and Myroxylon pereirae (MP) is common among European patients with dermatitis. Recently, FM II was included in the European baseline series as an additional marker of fragrance sensitization. OBJECTIVES: This literature review aims to assess the prevalence of fragrance sensitization in the general population, and to suggest how future population-based studies and questionnaires should be constructed, better to assess the prevalence and burden of fragrance sensitization. This is of relevance as it is often difficult to establish causality in biological systems. METHODS: A systematic review of the literature was carried out by searching Pubmed-Medline, Biosis and contact dermatitis textbooks. RESULTS: Nineteen studies were identified, of which 13 were performed among adults. Sample sizes varied between 82 and 2545 tested subjects, and 11 648 subjects were tested in total. The median prevalence of FM and MP sensitization among adults was 2.3% (women, 1.7%; men, 1.3%) and 1.1% (women, 1.4%; men, 0%), respectively. CONCLUSIONS: Based on the reliability of patch test data from the general population and exposure data obtained from patients with dermatitis, the prevalence and burden of fragrance sensitization in the general population is significant.
AB - BACKGROUND: Contact sensitization to fragrance mix (FM) I and Myroxylon pereirae (MP) is common among European patients with dermatitis. Recently, FM II was included in the European baseline series as an additional marker of fragrance sensitization. OBJECTIVES: This literature review aims to assess the prevalence of fragrance sensitization in the general population, and to suggest how future population-based studies and questionnaires should be constructed, better to assess the prevalence and burden of fragrance sensitization. This is of relevance as it is often difficult to establish causality in biological systems. METHODS: A systematic review of the literature was carried out by searching Pubmed-Medline, Biosis and contact dermatitis textbooks. RESULTS: Nineteen studies were identified, of which 13 were performed among adults. Sample sizes varied between 82 and 2545 tested subjects, and 11 648 subjects were tested in total. The median prevalence of FM and MP sensitization among adults was 2.3% (women, 1.7%; men, 1.3%) and 1.1% (women, 1.4%; men, 0%), respectively. CONCLUSIONS: Based on the reliability of patch test data from the general population and exposure data obtained from patients with dermatitis, the prevalence and burden of fragrance sensitization in the general population is significant.
U2 - 10.1111/j.1365-2133.2008.09022.x
DO - 10.1111/j.1365-2133.2008.09022.x
M3 - Journal article
C2 - 19210499
VL - 160
SP - 729
EP - 735
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 4
ER -
ID: 20319771