Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. / Sitnicka, Ewa; Brakebusch, Cord; Martensson, Inga-Lill; Svensson, Marcus; Agace, William W; Sigvardsson, Mikael; Buza-Vidas, Natalija; Bryder, David; Cilio, Corrado M; Ahlenius, Henrik; Maraskovsky, Eugene; Peschon, Jacques J; Jacobsen, Sten Eirik W.

In: Journal of Experimental Medicine, Vol. 198, No. 10, 2003, p. 1495-506.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sitnicka, E, Brakebusch, C, Martensson, I-L, Svensson, M, Agace, WW, Sigvardsson, M, Buza-Vidas, N, Bryder, D, Cilio, CM, Ahlenius, H, Maraskovsky, E, Peschon, JJ & Jacobsen, SEW 2003, 'Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.', Journal of Experimental Medicine, vol. 198, no. 10, pp. 1495-506. https://doi.org/10.1084/jem.20031152

APA

Sitnicka, E., Brakebusch, C., Martensson, I-L., Svensson, M., Agace, W. W., Sigvardsson, M., Buza-Vidas, N., Bryder, D., Cilio, C. M., Ahlenius, H., Maraskovsky, E., Peschon, J. J., & Jacobsen, S. E. W. (2003). Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. Journal of Experimental Medicine, 198(10), 1495-506. https://doi.org/10.1084/jem.20031152

Vancouver

Sitnicka E, Brakebusch C, Martensson I-L, Svensson M, Agace WW, Sigvardsson M et al. Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. Journal of Experimental Medicine. 2003;198(10):1495-506. https://doi.org/10.1084/jem.20031152

Author

Sitnicka, Ewa ; Brakebusch, Cord ; Martensson, Inga-Lill ; Svensson, Marcus ; Agace, William W ; Sigvardsson, Mikael ; Buza-Vidas, Natalija ; Bryder, David ; Cilio, Corrado M ; Ahlenius, Henrik ; Maraskovsky, Eugene ; Peschon, Jacques J ; Jacobsen, Sten Eirik W. / Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. In: Journal of Experimental Medicine. 2003 ; Vol. 198, No. 10. pp. 1495-506.

Bibtex

@article{53ebda00589511dd8d9f000ea68e967b,
title = "Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.",
abstract = "Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7Ralpha, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7Ralpha and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7Ralpha-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7Ralpha-/- mice, FL-/- x IL-7Ralpha-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development.",
author = "Ewa Sitnicka and Cord Brakebusch and Inga-Lill Martensson and Marcus Svensson and Agace, {William W} and Mikael Sigvardsson and Natalija Buza-Vidas and David Bryder and Cilio, {Corrado M} and Henrik Ahlenius and Eugene Maraskovsky and Peschon, {Jacques J} and Jacobsen, {Sten Eirik W}",
note = "Keywords: Animals; B-Lymphocytes; Cell Differentiation; Membrane Proteins; Mice; Mice, Knockout; Peyer's Patches; Receptors, Interleukin-7; Signal Transduction",
year = "2003",
doi = "10.1084/jem.20031152",
language = "English",
volume = "198",
pages = "1495--506",
journal = "The Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.

AU - Sitnicka, Ewa

AU - Brakebusch, Cord

AU - Martensson, Inga-Lill

AU - Svensson, Marcus

AU - Agace, William W

AU - Sigvardsson, Mikael

AU - Buza-Vidas, Natalija

AU - Bryder, David

AU - Cilio, Corrado M

AU - Ahlenius, Henrik

AU - Maraskovsky, Eugene

AU - Peschon, Jacques J

AU - Jacobsen, Sten Eirik W

N1 - Keywords: Animals; B-Lymphocytes; Cell Differentiation; Membrane Proteins; Mice; Mice, Knockout; Peyer's Patches; Receptors, Interleukin-7; Signal Transduction

PY - 2003

Y1 - 2003

N2 - Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7Ralpha, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7Ralpha and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7Ralpha-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7Ralpha-/- mice, FL-/- x IL-7Ralpha-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development.

AB - Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7Ralpha, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7Ralpha and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7Ralpha-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7Ralpha-/- mice, FL-/- x IL-7Ralpha-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7Ralpha are indispensable for fetal and adult B cell development.

U2 - 10.1084/jem.20031152

DO - 10.1084/jem.20031152

M3 - Journal article

C2 - 14610045

VL - 198

SP - 1495

EP - 1506

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

SN - 0022-1007

IS - 10

ER -

ID: 5141295