Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus
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Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus. / Eriksen, L.; Dahl-Petersen, I.; Haugaard, S. B.; Dela, F.
In: Diabetologia, Vol. 50, No. 11, 01.11.2007, p. 2245-2253.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus
AU - Eriksen, L.
AU - Dahl-Petersen, I.
AU - Haugaard, S. B.
AU - Dela, F.
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Aims/hypothesis: We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. Methods: Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two training programmes at 60% of maximal oxygen uptake: three 10 min sessions per day (3 x 10) or one 30 min session per day (1 x 30). Plasma insulin, C-peptide and glucose concentrations were measured during a 3 h oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI composite), pre-hepatic insulin secretion rates (ISR) and change in insulin secretion per unit change in glucose concentrations (Btotal) were calculated. Results: Cardiorespiratory fitness increased in response to training in both groups. In group 3 x 10 (n = 9) fasting plasma glucose (p = 0.01), 120 min glucose OGTT (p = 0.04) and plasma glucose concentration areas under the curve at 120 min (p < 0.04) and 180 min (p = 0.07) decreased. These parameters remained unchanged in group 1 x 30 (n = 9). No significant changes were found in ISIcomposite, ISR and Btotal in either of the exercise groups. In a matched time-control group (n = 10), glycaemic control did not change. Conclusions/interpretation: Moderate to high-intensity training performed at 3 x 10 min/day is preferable to 1 x 30 min/day with regard to effects on glycaemic control. This is in spite of the fact that cardiorespiratory fitness increased similarly in both exercise groups. A possible explanation is that the energy expenditure associated with multiple short daily sessions may be greater than that in a single daily session.
AB - Aims/hypothesis: We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. Methods: Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two training programmes at 60% of maximal oxygen uptake: three 10 min sessions per day (3 x 10) or one 30 min session per day (1 x 30). Plasma insulin, C-peptide and glucose concentrations were measured during a 3 h oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI composite), pre-hepatic insulin secretion rates (ISR) and change in insulin secretion per unit change in glucose concentrations (Btotal) were calculated. Results: Cardiorespiratory fitness increased in response to training in both groups. In group 3 x 10 (n = 9) fasting plasma glucose (p = 0.01), 120 min glucose OGTT (p = 0.04) and plasma glucose concentration areas under the curve at 120 min (p < 0.04) and 180 min (p = 0.07) decreased. These parameters remained unchanged in group 1 x 30 (n = 9). No significant changes were found in ISIcomposite, ISR and Btotal in either of the exercise groups. In a matched time-control group (n = 10), glycaemic control did not change. Conclusions/interpretation: Moderate to high-intensity training performed at 3 x 10 min/day is preferable to 1 x 30 min/day with regard to effects on glycaemic control. This is in spite of the fact that cardiorespiratory fitness increased similarly in both exercise groups. A possible explanation is that the energy expenditure associated with multiple short daily sessions may be greater than that in a single daily session.
KW - Cardiovascular fitness
KW - Energy expenditure
KW - Exercise
KW - Glycaemic control
KW - Insulin resistance
KW - Physical training
KW - Skeletal muscle
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=34848833307&partnerID=8YFLogxK
U2 - 10.1007/s00125-007-0783-0
DO - 10.1007/s00125-007-0783-0
M3 - Journal article
C2 - 17763840
AN - SCOPUS:34848833307
VL - 50
SP - 2245
EP - 2253
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 11
ER -
ID: 228208452