Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization. / Multhaupt, H; Bruder, E; Elit, L; Rothblat, I; Warhol, M.

In: Acta Cytologica, Vol. 37, No. 3, 1993, p. 373-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Multhaupt, H, Bruder, E, Elit, L, Rothblat, I & Warhol, M 1993, 'Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization.', Acta Cytologica, vol. 37, no. 3, pp. 373-8.

APA

Multhaupt, H., Bruder, E., Elit, L., Rothblat, I., & Warhol, M. (1993). Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization. Acta Cytologica, 37(3), 373-8.

Vancouver

Multhaupt H, Bruder E, Elit L, Rothblat I, Warhol M. Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization. Acta Cytologica. 1993;37(3):373-8.

Author

Multhaupt, H ; Bruder, E ; Elit, L ; Rothblat, I ; Warhol, M. / Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization. In: Acta Cytologica. 1993 ; Vol. 37, No. 3. pp. 373-8.

Bibtex

@article{747915605d4211dd8d9f000ea68e967b,
title = "Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization.",
abstract = "This study was an attempt to correlate the Bethesda System of Papanicolaou smear classification with DNA content by image analysis and the presence of human papillomavirus (HPV) as determined by in situ hybridization. DNA histograms were classified as normal diploid, diploid proliferative, polyploid and aneuploid. HPV in situ hybridization was performed with a cocktail of probes specific to HPV types 6, 11, 16 and 18. There was a good correlation between normal cytology and normal DNA histograms. Cytologically normal smears with bacterial or fungal infections showed a high proliferation index. HPV infection correlated with DNA polyploidy but was seen in 15 of 29 smears classified as cytologically normal. Morphologically abnormal Papanicolaou smears correlated with aneuploid DNA content. Smears classified as intraepithelial neoplasia correlated with aneuploid DNA content in all 12 cases. Four of five cases cytologically suspicious for HPV infection had HPV by in situ hybridization.",
author = "H Multhaupt and E Bruder and L Elit and I Rothblat and M Warhol",
note = "Keywords: Aneuploidy; Cell Transformation, Neoplastic; Coloring Agents; DNA, Neoplasm; DNA, Viral; Female; Flow Cytometry; Humans; Image Processing, Computer-Assisted; In Situ Hybridization; Papillomaviridae; Ploidies; Rosaniline Dyes; Tumor Virus Infections; Uterine Cervical Diseases; Uterine Cervical Neoplasms; Vaginal Smears",
year = "1993",
language = "English",
volume = "37",
pages = "373--8",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Combined analysis of cervical smears. Cytopathology, image cytometry and in situ hybridization.

AU - Multhaupt, H

AU - Bruder, E

AU - Elit, L

AU - Rothblat, I

AU - Warhol, M

N1 - Keywords: Aneuploidy; Cell Transformation, Neoplastic; Coloring Agents; DNA, Neoplasm; DNA, Viral; Female; Flow Cytometry; Humans; Image Processing, Computer-Assisted; In Situ Hybridization; Papillomaviridae; Ploidies; Rosaniline Dyes; Tumor Virus Infections; Uterine Cervical Diseases; Uterine Cervical Neoplasms; Vaginal Smears

PY - 1993

Y1 - 1993

N2 - This study was an attempt to correlate the Bethesda System of Papanicolaou smear classification with DNA content by image analysis and the presence of human papillomavirus (HPV) as determined by in situ hybridization. DNA histograms were classified as normal diploid, diploid proliferative, polyploid and aneuploid. HPV in situ hybridization was performed with a cocktail of probes specific to HPV types 6, 11, 16 and 18. There was a good correlation between normal cytology and normal DNA histograms. Cytologically normal smears with bacterial or fungal infections showed a high proliferation index. HPV infection correlated with DNA polyploidy but was seen in 15 of 29 smears classified as cytologically normal. Morphologically abnormal Papanicolaou smears correlated with aneuploid DNA content. Smears classified as intraepithelial neoplasia correlated with aneuploid DNA content in all 12 cases. Four of five cases cytologically suspicious for HPV infection had HPV by in situ hybridization.

AB - This study was an attempt to correlate the Bethesda System of Papanicolaou smear classification with DNA content by image analysis and the presence of human papillomavirus (HPV) as determined by in situ hybridization. DNA histograms were classified as normal diploid, diploid proliferative, polyploid and aneuploid. HPV in situ hybridization was performed with a cocktail of probes specific to HPV types 6, 11, 16 and 18. There was a good correlation between normal cytology and normal DNA histograms. Cytologically normal smears with bacterial or fungal infections showed a high proliferation index. HPV infection correlated with DNA polyploidy but was seen in 15 of 29 smears classified as cytologically normal. Morphologically abnormal Papanicolaou smears correlated with aneuploid DNA content. Smears classified as intraepithelial neoplasia correlated with aneuploid DNA content in all 12 cases. Four of five cases cytologically suspicious for HPV infection had HPV by in situ hybridization.

M3 - Journal article

C2 - 8388610

VL - 37

SP - 373

EP - 378

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 3

ER -

ID: 5240397