Collagen biology and non-invasive biomarkers of liver fibrosis

Research output: Contribution to journal › Review › Research › peer-review

Standard

Collagen biology and non-invasive biomarkers of liver fibrosis. / Karsdal, Morten A.; Daniels, Samuel J.; Holm Nielsen, Signe; Bager, Cecilie; Rasmussen, Daniel G.K.; Loomba, Rohit; Surabattula, Rambabu; Villesen, Ida Falk; Luo, Yi; Shevell, Diane; Gudmann, Natasja S.; Nielsen, Mette J.; George, Jacob; Christian, Rose; Leeming, Diana J.; Schuppan, Detlef.

In: Liver International, Vol. 40, No. 4, 2020, p. 736-750.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Karsdal, MA, Daniels, SJ, Holm Nielsen, S, Bager, C, Rasmussen, DGK, Loomba, R, Surabattula, R, Villesen, IF, Luo, Y, Shevell, D, Gudmann, NS, Nielsen, MJ, George, J, Christian, R, Leeming, DJ & Schuppan, D 2020, 'Collagen biology and non-invasive biomarkers of liver fibrosis', Liver International, vol. 40, no. 4, pp. 736-750. https://doi.org/10.1111/liv.14390

APA

Karsdal, M. A., Daniels, S. J., Holm Nielsen, S., Bager, C., Rasmussen, D. G. K., Loomba, R., Surabattula, R., Villesen, I. F., Luo, Y., Shevell, D., Gudmann, N. S., Nielsen, M. J., George, J., Christian, R., Leeming, D. J., & Schuppan, D. (2020). Collagen biology and non-invasive biomarkers of liver fibrosis. Liver International, 40(4), 736-750. https://doi.org/10.1111/liv.14390

Vancouver

Karsdal MA, Daniels SJ, Holm Nielsen S, Bager C, Rasmussen DGK, Loomba R et al. Collagen biology and non-invasive biomarkers of liver fibrosis. Liver International. 2020;40(4):736-750. https://doi.org/10.1111/liv.14390

Author

Karsdal, Morten A. ; Daniels, Samuel J. ; Holm Nielsen, Signe ; Bager, Cecilie ; Rasmussen, Daniel G.K. ; Loomba, Rohit ; Surabattula, Rambabu ; Villesen, Ida Falk ; Luo, Yi ; Shevell, Diane ; Gudmann, Natasja S. ; Nielsen, Mette J. ; George, Jacob ; Christian, Rose ; Leeming, Diana J. ; Schuppan, Detlef. / Collagen biology and non-invasive biomarkers of liver fibrosis. In: Liver International. 2020 ; Vol. 40, No. 4. pp. 736-750.

Bibtex

@article{056b759a664a410fa1a1aadae5377f56,

title = "Collagen biology and non-invasive biomarkers of liver fibrosis",

abstract = "There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.",

keywords = "biomarker, cirrhosis, collagen, fibrogenesis, fibrolysis, fibrosis, HBV, HCV, liver, monitoring, NAFLD, NASH, non-invasive, peptide, plasma, procollagen, serum, treatment",

author = "Karsdal, {Morten A.} and Daniels, {Samuel J.} and {Holm Nielsen}, Signe and Cecilie Bager and Rasmussen, {Daniel G.K.} and Rohit Loomba and Rambabu Surabattula and Villesen, {Ida Falk} and Yi Luo and Diane Shevell and Gudmann, {Natasja S.} and Nielsen, {Mette J.} and Jacob George and Rose Christian and Leeming, {Diana J.} and Detlef Schuppan",

note = "Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2020",

doi = "10.1111/liv.14390",

language = "English",

volume = "40",

pages = "736--750",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley-Blackwell",

number = "4",

}

RIS

TY - JOUR

T1 - Collagen biology and non-invasive biomarkers of liver fibrosis

AU - Karsdal, Morten A.

AU - Daniels, Samuel J.

AU - Holm Nielsen, Signe

AU - Bager, Cecilie

AU - Rasmussen, Daniel G.K.

AU - Loomba, Rohit

AU - Surabattula, Rambabu

AU - Villesen, Ida Falk

AU - Luo, Yi

AU - Shevell, Diane

AU - Gudmann, Natasja S.

AU - Nielsen, Mette J.

AU - George, Jacob

AU - Christian, Rose

AU - Leeming, Diana J.

AU - Schuppan, Detlef

PY - 2020

Y1 - 2020

N2 - There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.

AB - There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.

KW - biomarker

KW - cirrhosis

KW - collagen

KW - fibrogenesis

KW - fibrolysis

KW - fibrosis

KW - HBV

KW - HCV

KW - liver

KW - monitoring

KW - NAFLD

KW - NASH

KW - non-invasive

KW - peptide

KW - plasma

KW - procollagen

KW - serum

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=85079714960&partnerID=8YFLogxK

U2 - 10.1111/liv.14390

DO - 10.1111/liv.14390

M3 - Review

C2 - 31997561

AN - SCOPUS:85079714960

VL - 40

SP - 736

EP - 750

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 4

ER -

ID: 270628556

Department of Biomedical Sciences