Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine
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Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine. / Vinter-Jensen, Lars; Smerup, Morten Holdgaard; Kissmeyer-Nielsen, Peter; Poulsen, Steen Seier.
In: Regulatory Peptides, Vol. 60, No. 2-3, 14.12.1995, p. 117-24.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic systemic treatment with epidermal growth factor in the rat increases the mucosal surface of the small intestine
AU - Vinter-Jensen, Lars
AU - Smerup, Morten Holdgaard
AU - Kissmeyer-Nielsen, Peter
AU - Poulsen, Steen Seier
PY - 1995/12/14
Y1 - 1995/12/14
N2 - We examined the effects of treatment with human recombinant epidermal growth factor (EGF) on the functioning small intestine in the rat. Male Wistar rats, 7-8 weeks old, were treated with EGF administered subcutaneously in doses of 0 (n = 7) or 150 micrograms/kg/day (n = 8) for 4 weeks. The histological composition and mucosal surface area of the perfusion-fixed small intestine was quantified with stereological principles. The length of the gut remained unchanged. The amount of tissue and surface area per length of gut (median (ranges)) were increased from 117 (101-131) mg/cm and 2.6 (2.1-3.5) cm2/cm in the controls to 146 (138-152) mg/cm and 3.5 (2.5-3.8) cm2/cm for the complete small intestine (both comparisons P <0.02). The weight increase was due to mucosal growth in all parts of the intestine, whereas the surface area was only increased in proximal and middle parts. It is concluded that EGF treatment in rats increases the mucosal weight and surface area of the functioning small intestine.
AB - We examined the effects of treatment with human recombinant epidermal growth factor (EGF) on the functioning small intestine in the rat. Male Wistar rats, 7-8 weeks old, were treated with EGF administered subcutaneously in doses of 0 (n = 7) or 150 micrograms/kg/day (n = 8) for 4 weeks. The histological composition and mucosal surface area of the perfusion-fixed small intestine was quantified with stereological principles. The length of the gut remained unchanged. The amount of tissue and surface area per length of gut (median (ranges)) were increased from 117 (101-131) mg/cm and 2.6 (2.1-3.5) cm2/cm in the controls to 146 (138-152) mg/cm and 3.5 (2.5-3.8) cm2/cm for the complete small intestine (both comparisons P <0.02). The weight increase was due to mucosal growth in all parts of the intestine, whereas the surface area was only increased in proximal and middle parts. It is concluded that EGF treatment in rats increases the mucosal weight and surface area of the functioning small intestine.
KW - Animals
KW - Epidermal Growth Factor
KW - Intestinal Mucosa
KW - Intestine, Small
KW - Male
KW - Random Allocation
KW - Rats
KW - Rats, Wistar
KW - Recombinant Proteins
KW - Surface Properties
KW - Time Factors
M3 - Journal article
C2 - 8746538
VL - 60
SP - 117
EP - 124
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
IS - 2-3
ER -
ID: 47486982