Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates
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Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates. / Vinter-Jensen, Lars; Juhl, C O; Poulsen, Steen Seier; Djurhuus, Jens Christian; Dajani, E Z; Nexø, Ebba.
In: Laboratory Investigation, Vol. 73, No. 6, 12.1995, p. 788-93.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates
AU - Vinter-Jensen, Lars
AU - Juhl, C O
AU - Poulsen, Steen Seier
AU - Djurhuus, Jens Christian
AU - Dajani, E Z
AU - Nexø, Ebba
PY - 1995/12
Y1 - 1995/12
N2 - Epidermal growth factor (EGF) receptor hyperstimulation induced by systemically administered EGF or by the development of transgenic mice overexpressing transforming growth factor alpha (TGF alpha) or other EGF-related ligands is known to induce various effects, such as acceleration of developmental processes like incisor eruption, inhibition of gastric acid secretion, morphologic changes in the pancreas resembling pancreatitis, and malignancies in mammary glands and the liver. The present investigation was initiated to explore the effects of systemic EGF administration to the mature organism in a species with greater anatomic resemblance to humans than rodents.
AB - Epidermal growth factor (EGF) receptor hyperstimulation induced by systemically administered EGF or by the development of transgenic mice overexpressing transforming growth factor alpha (TGF alpha) or other EGF-related ligands is known to induce various effects, such as acceleration of developmental processes like incisor eruption, inhibition of gastric acid secretion, morphologic changes in the pancreas resembling pancreatitis, and malignancies in mammary glands and the liver. The present investigation was initiated to explore the effects of systemic EGF administration to the mature organism in a species with greater anatomic resemblance to humans than rodents.
KW - Animals
KW - Digestive System
KW - Epidermal Growth Factor
KW - Female
KW - Glycoconjugates
KW - Hyperplasia
KW - Lung
KW - Male
KW - Pancreas
KW - Salivary Glands
KW - Swine
KW - Urinary Tract
M3 - Journal article
C2 - 8558839
VL - 73
SP - 788
EP - 793
JO - Laboratory Investigation
JF - Laboratory Investigation
SN - 0023-6837
IS - 6
ER -
ID: 47487006