Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3. / Suri, Bani Kaur; Schmidtchen, Artur; Verma, Navin Kumar.

In: Experimental Dermatology, Vol. 28, No. 8, 2019, p. 976-980.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Suri, BK, Schmidtchen, A & Verma, NK 2019, 'Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3', Experimental Dermatology, vol. 28, no. 8, pp. 976-980. https://doi.org/10.1111/exd.13976

APA

Suri, B. K., Schmidtchen, A., & Verma, N. K. (2019). Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3. Experimental Dermatology, 28(8), 976-980. https://doi.org/10.1111/exd.13976

Vancouver

Suri BK, Schmidtchen A, Verma NK. Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3. Experimental Dermatology. 2019;28(8):976-980. https://doi.org/10.1111/exd.13976

Author

Suri, Bani Kaur ; Schmidtchen, Artur ; Verma, Navin Kumar. / Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3. In: Experimental Dermatology. 2019 ; Vol. 28, No. 8. pp. 976-980.

Bibtex

@article{69fff1a5b01c46b5b81907781f40d9d6,
title = "Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3",
abstract = "Carbonic anhydrases (CAs) are ubiquitously expressed enzymes and catalyse an important physiological reaction of interconverting the hydration of carbon dioxide to bicarbonates, which is crucial for maintaining acid/base equilibrium in certain tissues. While 15 different isoforms of CAs are present in various cell types in human tissues, their expression pattern in the epidermis remains to be investigated. Here, we report the expression of 5 CA isoforms (CAII, CAIX, CAXI, CAXII and CAXIII) in human primary keratinocytes. Further, we demonstrate that the expression of CAII and CAIX in these cells is significantly up-regulated by the biologically active metabolites of vitamin A (all-trans retinoic acid) and vitamin D (1 alpha,25-dihydroxyvitamin D-3), respectively. Taken together, apart from providing new information on the expression of CAs in the skin, our results highlight a previously undisclosed connection between vitamin A and CAII expression and vitamin D and CAIX expression.",
keywords = "carbonic anhydrases, retinoic acid, vitamin A, vitamin D",
author = "Suri, {Bani Kaur} and Artur Schmidtchen and Verma, {Navin Kumar}",
year = "2019",
doi = "10.1111/exd.13976",
language = "English",
volume = "28",
pages = "976--980",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D-3

AU - Suri, Bani Kaur

AU - Schmidtchen, Artur

AU - Verma, Navin Kumar

PY - 2019

Y1 - 2019

N2 - Carbonic anhydrases (CAs) are ubiquitously expressed enzymes and catalyse an important physiological reaction of interconverting the hydration of carbon dioxide to bicarbonates, which is crucial for maintaining acid/base equilibrium in certain tissues. While 15 different isoforms of CAs are present in various cell types in human tissues, their expression pattern in the epidermis remains to be investigated. Here, we report the expression of 5 CA isoforms (CAII, CAIX, CAXI, CAXII and CAXIII) in human primary keratinocytes. Further, we demonstrate that the expression of CAII and CAIX in these cells is significantly up-regulated by the biologically active metabolites of vitamin A (all-trans retinoic acid) and vitamin D (1 alpha,25-dihydroxyvitamin D-3), respectively. Taken together, apart from providing new information on the expression of CAs in the skin, our results highlight a previously undisclosed connection between vitamin A and CAII expression and vitamin D and CAIX expression.

AB - Carbonic anhydrases (CAs) are ubiquitously expressed enzymes and catalyse an important physiological reaction of interconverting the hydration of carbon dioxide to bicarbonates, which is crucial for maintaining acid/base equilibrium in certain tissues. While 15 different isoforms of CAs are present in various cell types in human tissues, their expression pattern in the epidermis remains to be investigated. Here, we report the expression of 5 CA isoforms (CAII, CAIX, CAXI, CAXII and CAXIII) in human primary keratinocytes. Further, we demonstrate that the expression of CAII and CAIX in these cells is significantly up-regulated by the biologically active metabolites of vitamin A (all-trans retinoic acid) and vitamin D (1 alpha,25-dihydroxyvitamin D-3), respectively. Taken together, apart from providing new information on the expression of CAs in the skin, our results highlight a previously undisclosed connection between vitamin A and CAII expression and vitamin D and CAIX expression.

KW - carbonic anhydrases

KW - retinoic acid

KW - vitamin A

KW - vitamin D

U2 - 10.1111/exd.13976

DO - 10.1111/exd.13976

M3 - Journal article

C2 - 31125456

VL - 28

SP - 976

EP - 980

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 8

ER -

ID: 225555774