beta-Arrestin 1 and 2 stabilize the angiotensin II type I receptor in distinct high-affinity conformations
Research output: Contribution to journal › Journal article › Research › peer-review
The angiotensin II type 1 (AT(1)) receptor belongs to family A of 7 transmembrane (7TM) receptors. The receptor has important roles in the cardiovascular system and is commonly used as a drug target in cardiovascular diseases. Interaction of 7TM receptors with G proteins or beta-arrestins often induces higher binding affinity for agonists. Here, we examined interactions between AT(1A) receptors and beta-arrestins to look for differences between the AT(1A) receptor interaction with beta-arrestin1 and beta-arrestin2.
| Original language | English |
|---|---|
| Journal | British Journal of Pharmacology |
| Volume | 161 |
| Issue number | 1 |
| Pages (from-to) | 150-61 |
| Number of pages | 12 |
| ISSN | 0007-1188 |
| DOIs | |
| Publication status | Published - Sep 2010 |
- Animals, Arrestins, Cell Line, GTP-Binding Proteins, Humans, Protein Conformation, Receptor, Angiotensin, Type 1, Signal Transduction
Research areas
ID: 34167999