Atrial distension, haemodilution, and acute control of renin release during water immersion in humans

Research output: Contribution to journal › Journal article › Research › peer-review

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Atrial distension, haemodilution, and acute control of renin release during water immersion in humans. / Gabrielsen, A; Pump, B; Bie, P; Christensen, N J; Warberg, J; Norsk, P.

In: Acta Physiologica Scandinavica. Supplementum, Vol. 174, No. 2, 01.02.2002, p. 91-99.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gabrielsen, A, Pump, B, Bie, P, Christensen, NJ, Warberg, J & Norsk, P 2002, 'Atrial distension, haemodilution, and acute control of renin release during water immersion in humans', Acta Physiologica Scandinavica. Supplementum, vol. 174, no. 2, pp. 91-99.

APA

Gabrielsen, A., Pump, B., Bie, P., Christensen, N. J., Warberg, J., & Norsk, P. (2002). Atrial distension, haemodilution, and acute control of renin release during water immersion in humans. Acta Physiologica Scandinavica. Supplementum, 174(2), 91-99.

Vancouver

Gabrielsen A, Pump B, Bie P, Christensen NJ, Warberg J, Norsk P. Atrial distension, haemodilution, and acute control of renin release during water immersion in humans. Acta Physiologica Scandinavica. Supplementum. 2002 Feb 1;174(2):91-99.

Author

Gabrielsen, A ; Pump, B ; Bie, P ; Christensen, N J ; Warberg, J ; Norsk, P. / Atrial distension, haemodilution, and acute control of renin release during water immersion in humans. In: Acta Physiologica Scandinavica. Supplementum. 2002 ; Vol. 174, No. 2. pp. 91-99.

Bibtex

@article{1a3d990074c711dbbee902004c4f4f50,
title = "Atrial distension, haemodilution, and acute control of renin release during water immersion in humans",
abstract = "We tested the hypothesis that atrial distension (stimulation of cardiopulmonary baroreceptors) is not the single pivotal stimulus for the acute suppression of renin release during water immersion in humans and that immersion-induced haemodilution constitutes an important additional stimulus. In nine healthy male subjects, identical increases in atrial distension were induced by two immersion procedures (of 30 min each); one without (WI) and one with attenuation (WI + cuff) of the concomitant haemodilution (estimated from changes in plasma protein concentration) by inflating thigh cuffs during immersion. During WI, central venous pressure (CVP) and left atrial diameter (LAD) increased (P <0.05) by 5.5 +/- 0.4 mmHg and 4.6 +/- 0.5 mm, respectively, and plasma protein concentration and plasma renin activity (PRA) progressively decreased (P <0.05) by 4.8 +/- 0.5 g L(-1) and 1.6 +/- 0.2 ng mL(-1) h(-1) (to 49 +/- 4% of baseline values), respectively. The WI + cuff caused similar atrial distension as WI (CVP and LAD increased by 6.9 +/- 0.5 mmHg and 5.5 +/- 0.5 mm, respectively), attenuated haemodilution (plasma protein concentration decreased by 1.9 +/- 0.4 g L(-1), P <0.05 vs. WI), and markedly inhibited suppression of PRA, which decreased by 0.4 +/- 0.1 ng mL(-1) h(-1) (to 87 +/- 4% of baseline values, P <0.05 vs. WI). Differences in renin release could not be accounted for by differences in mean arterial pressure. In conclusion, baroreceptor stimulation induced by atrial distension is not the single pivotal stimulus for the acute suppression of renin release in response to intravascular volume expansion by water immersion in humans. Haemodilution constitutes a significant and conceivably the principal stimulus for the acute immersion-induced suppression of renin-angiotensin system activity.",
keywords = "Adult, Angiotensin II, Atrial Function, Blood Pressure, Blood Proteins, Heart Rate, Hemodilution, Humans, Immersion, Male, Norepinephrine, Osmotic Pressure, Plasma Volume, Pressoreceptors, Renin, Sympathetic Nervous System",
author = "A Gabrielsen and B Pump and P Bie and Christensen, {N J} and J Warberg and P Norsk",
year = "2002",
month = feb,
day = "1",
language = "English",
volume = "174",
pages = "91--99",
journal = "Acta Physiologica Scandinavica",
issn = "0001-6772",
publisher = "Blackwell Science Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Atrial distension, haemodilution, and acute control of renin release during water immersion in humans

AU - Gabrielsen, A

AU - Pump, B

AU - Bie, P

AU - Christensen, N J

AU - Warberg, J

AU - Norsk, P

PY - 2002/2/1

Y1 - 2002/2/1

N2 - We tested the hypothesis that atrial distension (stimulation of cardiopulmonary baroreceptors) is not the single pivotal stimulus for the acute suppression of renin release during water immersion in humans and that immersion-induced haemodilution constitutes an important additional stimulus. In nine healthy male subjects, identical increases in atrial distension were induced by two immersion procedures (of 30 min each); one without (WI) and one with attenuation (WI + cuff) of the concomitant haemodilution (estimated from changes in plasma protein concentration) by inflating thigh cuffs during immersion. During WI, central venous pressure (CVP) and left atrial diameter (LAD) increased (P <0.05) by 5.5 +/- 0.4 mmHg and 4.6 +/- 0.5 mm, respectively, and plasma protein concentration and plasma renin activity (PRA) progressively decreased (P <0.05) by 4.8 +/- 0.5 g L(-1) and 1.6 +/- 0.2 ng mL(-1) h(-1) (to 49 +/- 4% of baseline values), respectively. The WI + cuff caused similar atrial distension as WI (CVP and LAD increased by 6.9 +/- 0.5 mmHg and 5.5 +/- 0.5 mm, respectively), attenuated haemodilution (plasma protein concentration decreased by 1.9 +/- 0.4 g L(-1), P <0.05 vs. WI), and markedly inhibited suppression of PRA, which decreased by 0.4 +/- 0.1 ng mL(-1) h(-1) (to 87 +/- 4% of baseline values, P <0.05 vs. WI). Differences in renin release could not be accounted for by differences in mean arterial pressure. In conclusion, baroreceptor stimulation induced by atrial distension is not the single pivotal stimulus for the acute suppression of renin release in response to intravascular volume expansion by water immersion in humans. Haemodilution constitutes a significant and conceivably the principal stimulus for the acute immersion-induced suppression of renin-angiotensin system activity.

AB - We tested the hypothesis that atrial distension (stimulation of cardiopulmonary baroreceptors) is not the single pivotal stimulus for the acute suppression of renin release during water immersion in humans and that immersion-induced haemodilution constitutes an important additional stimulus. In nine healthy male subjects, identical increases in atrial distension were induced by two immersion procedures (of 30 min each); one without (WI) and one with attenuation (WI + cuff) of the concomitant haemodilution (estimated from changes in plasma protein concentration) by inflating thigh cuffs during immersion. During WI, central venous pressure (CVP) and left atrial diameter (LAD) increased (P <0.05) by 5.5 +/- 0.4 mmHg and 4.6 +/- 0.5 mm, respectively, and plasma protein concentration and plasma renin activity (PRA) progressively decreased (P <0.05) by 4.8 +/- 0.5 g L(-1) and 1.6 +/- 0.2 ng mL(-1) h(-1) (to 49 +/- 4% of baseline values), respectively. The WI + cuff caused similar atrial distension as WI (CVP and LAD increased by 6.9 +/- 0.5 mmHg and 5.5 +/- 0.5 mm, respectively), attenuated haemodilution (plasma protein concentration decreased by 1.9 +/- 0.4 g L(-1), P <0.05 vs. WI), and markedly inhibited suppression of PRA, which decreased by 0.4 +/- 0.1 ng mL(-1) h(-1) (to 87 +/- 4% of baseline values, P <0.05 vs. WI). Differences in renin release could not be accounted for by differences in mean arterial pressure. In conclusion, baroreceptor stimulation induced by atrial distension is not the single pivotal stimulus for the acute suppression of renin release in response to intravascular volume expansion by water immersion in humans. Haemodilution constitutes a significant and conceivably the principal stimulus for the acute immersion-induced suppression of renin-angiotensin system activity.

KW - Adult

KW - Angiotensin II

KW - Atrial Function

KW - Blood Pressure

KW - Blood Proteins

KW - Heart Rate

KW - Hemodilution

KW - Humans

KW - Immersion

KW - Male

KW - Norepinephrine

KW - Osmotic Pressure

KW - Plasma Volume

KW - Pressoreceptors

KW - Renin

KW - Sympathetic Nervous System

M3 - Journal article

C2 - 11860370

VL - 174

SP - 91

EP - 99

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0001-6772

IS - 2

ER -

ID: 162510